5-methyl-1-(4-methylbenzyl)-3-{4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}-1H-pyrazole

Base Information

Chemical Name:5-methyl-1-(4-methylbenzyl)-3-{4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}-1H-pyrazole
CAS No.:1085451-95-1
Molecular Formula:C₂₂H₁₉F₃N₄O
Molecular Weight:412.414
Hs Code.:

Synonyms:5-methyl-1-(4-methylbenzyl)-3-{4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}-1H-pyrazole

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Chemical Property of 5-methyl-1-(4-methylbenzyl)-3-{4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}-1H-pyrazole

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Technology Process of 5-methyl-1-(4-methylbenzyl)-3-{4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}-1H-pyrazole

There total 5 articles about 5-methyl-1-(4-methylbenzyl)-3-{4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 856905-30-1
5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylic acid

: 103962-10-3
2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanone

: 1085451-95-1
5-methyl-1-(4-methylbenzyl)-3-{4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}-1H-pyrazole

Guidance literature:: 5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylic acid; With caesium carbonate; In ethanol; at 20 ℃; for 0.5h;

2-bromo-1-(4-(trifluoromethoxy)phenyl)ethanone; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With ammonium acetate; In xylene; for 2h; Heating / reflux;

Reference yield:

: 1085453-43-5
tert-butyl 2-isopropylidene-1-(4-methylbenzyl)hydrazine-carboxylate

: 1085451-95-1
5-methyl-1-(4-methylbenzyl)-3-{4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 3 h / Heating / reflux

2.1: acetic acid / 4 h / 90 °C

3.1: sodium hydroxide; water / ethanol / 16 h / 70 °C

4.1: caesium carbonate / ethanol / 0.5 h / 20 °C

4.2: 2 h / 20 °C

4.3: 2 h / Heating / reflux

With hydrogenchloride; sodium hydroxide; water; caesium carbonate; acetic acid; In tetrahydrofuran; ethanol;

Reference yield:

: 1085453-45-7
methyl 5-methyl-1-(4-methylbenzyl)-1H-pyrazole-3-carboxylate

: 1085451-95-1
5-methyl-1-(4-methylbenzyl)-3-{4-[4-(trifluoromethoxy)phenyl]-1H-imidazol-2-yl}-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 16 h / 70 °C

2.1: caesium carbonate / ethanol / 0.5 h / 20 °C

2.2: 2 h / 20 °C

2.3: 2 h / Heating / reflux

With sodium hydroxide; water; caesium carbonate; In ethanol;