5-(tert-butyl-diphenyl-silanyloxy)-1,1-dideuterio-pent-2-yn-1-ol

Base Information

• Chemical Name: 5-(tert-butyl-diphenyl-silanyloxy)-1,1-dideuterio-pent-2-yn-1-ol
• CAS No.: 668988-55-4
• Molecular Formula: C₂₁H₂₆O₂Si
• Molecular Weight: 340.506
• Mol file: 668988-55-4.mol

Synonyms:5-(tert-butyl-diphenyl-silanyloxy)-1,1-dideuterio-pent-2-yn-1-ol

Chemical Property of 5-(tert-butyl-diphenyl-silanyloxy)-1,1-dideuterio-pent-2-yn-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(tert-butyl-diphenyl-silanyloxy)-1,1-dideuterio-pent-2-yn-1-ol

There total 1 articles about 5-(tert-butyl-diphenyl-silanyloxy)-1,1-dideuterio-pent-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

paraformaldehyde-d2 (1664-98-8,43094-80-0) + 4-(tert-butyldiphenylsilyloxy)-1-butyne (88158-68-3) → 5-(tert-butyl-diphenyl-silanyloxy)-1,1-dideuterio-pent-2-yn-1-ol (668988-55-4)

Guidance literature:

4-(tert-butyldiphenylsilyloxy)-1-butyne; With ethylmagnesium bromide; In tetrahydrofuran; for 2h; Heating;

paraformaldehyde-d2; In tetrahydrofuran; for 3h; Heating;

DOI:10.1021/ol0361711

Reference yield: 69.0%

5-(tert-butyl-diphenyl-silanyloxy)-1,1-dideuterio-pent-2-yn-1-ol (668988-55-4) → (5-bromo-5,5-dideuterio-pent-3-ynyloxy)-tert-butyl-diphenyl-silane (668988-56-5)

Guidance literature:

With pyridine; carbon tetrabromide; triphenylphosphine; In dichloromethane; at 25 ℃; for 4h;

DOI:10.1021/ol0361711

Reference yield:

5-(tert-butyl-diphenyl-silanyloxy)-1,1-dideuterio-pent-2-yn-1-ol (668988-55-4) → tert-butyl-(5,5-dideuterio-dodeca-3,6-dienyloxy)-diphenyl-silane (668988-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 69 percent / triphenylphosphine; carbon tetrabromide; pyridine / CH₂Cl₂ / 4 h / 25 °C

2.1: ethylmagnesium bromide / tetrahydrofuran / 1 h / Heating

2.2: 86 percent / copper(I) bromide / tetrahydrofuran / Heating

3.1: 63 percent / hydrogen; nickel(II) acetate tetrahydrate; sodium borohydride / sodium hydroxide; ethylenediamine / ethanol; H₂O / 20 °C

With pyridine; sodium tetrahydroborate; carbon tetrabromide; ethylmagnesium bromide; hydrogen; nickel diacetate; triphenylphosphine; sodium hydroxide; ethylenediamine; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/ol0361711

upstream raw materials:

paraformaldehyde-d2

4-(tert-butyldiphenylsilyloxy)-1-butyne

Downstream raw materials:

(5-bromo-5,5-dideuterio-pent-3-ynyloxy)-tert-butyl-diphenyl-silane

tert-butyl-(5,5-dideuterio-dodeca-3,6-dienyloxy)-diphenyl-silane

tert-butyl-(5,5-dideuterio-dodeca-3,6-diynyloxy)-diphenyl-silane