C₄₅H₅₅FN₈O₆

Base Information

• Chemical Name: C₄₅H₅₅FN₈O₆
• CAS No.: 1560649-05-9
• Molecular Formula: C₄₅H₅₅FN₈O₆
• Molecular Weight: 822.98
• Mol file: 1560649-05-9.mol

Synonyms:C₄₅H₅₅FN₈O₆

Chemical Property of C₄₅H₅₅FN₈O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₅H₅₅FN₈O₆

There total 18 articles about C₄₅H₅₅FN₈O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.18%

C31H33FN6*4ClH + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → C45H55FN8O6 (1560649-05-9)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -10 - 20 ℃;

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → C45H55FN8O6 (1560649-05-9)

Guidance literature:

Multi-step reaction with 8 steps

1: diborane / tetrahydrofuran / 3 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

3: ammonia / methanol / 0 - 20 °C

4: N-iodo-succinimide / dichloromethane / 1.5 h / 0 °C

5: water; sodium sulfite / ethanol / 17 h / Reflux

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water / 3 h / 90 °C / Inert atmosphere

7: hydrogenchloride / ethyl acetate / 20 °C

8: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1-hydroxy-7-aza-benzotriazole / dichloromethane / -10 - 20 °C

With hydrogenchloride; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; ammonia; water; potassium carbonate; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; diborane; sodium sulfite; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

p-benzoquinone (106-51-4) → C45H55FN8O6 (1560649-05-9)

Guidance literature:

Multi-step reaction with 9 steps

1: dichloromethane / 1.5 h / -10 - 20 °C

2: sodium acetate; methanol / 3 h / 50 °C / Inert atmosphere

3: palladium on activated charcoal; hydrogen / methanol / 1.5 h / 20 °C / 760.05 Torr

4: pyridine / dichloromethane / 1 h / 0 - 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium fluoride / 1,2-dimethoxyethane; water / 3 h / 90 °C / Inert atmosphere

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,2-dimethoxyethane / 120 °C / Inert atmosphere

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water / 3 h / 90 °C / Inert atmosphere

8: hydrogenchloride / ethyl acetate / 20 °C

9: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1-hydroxy-7-aza-benzotriazole / dichloromethane / -10 - 20 °C

With pyridine; hydrogenchloride; methanol; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; hydrogen; potassium acetate; sodium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate;

upstream raw materials:

N-methoxycarbonyl-L-valine

1-(tert-butoxycarbonyl)-L-proline

p-benzoquinone

1,4,4a,8a-tetrahydro-1,4-methanonaphthalene-5,8-dione