2-[(1R)-2-HYDROXY-1-METHYLETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE

Base Information

• Chemical Name: 2-[(1R)-2-HYDROXY-1-METHYLETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE
• CAS No.: 73323-91-8
• Molecular Formula: C11H11 N O3
• Molecular Weight: 205.213
• Mol file: 73323-91-8.mol

Synonyms:1H-Isoindole-1,3(2H)-dione,2-(2-hydroxy-1-methylethyl)-, (R)-; (R)-2-(2-Hydroxy-1-methyl-ethyl)-isoindol-1,3-dione

Chemical Property of 2-[(1R)-2-HYDROXY-1-METHYLETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE

Chemical Property:

• Boiling Point: 357℃
• Flash Point: 170℃
• PSA: 57.61000
• Density: 1.348
• LogP: 0.60130

Purity/Quality:

97% ^*data from raw suppliers

2-[(2R)-1-hydroxypropan-2-yl]-2,3-dihydro-1H-isoindole-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(1R)-2-HYDROXY-1-METHYLETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE

There total 2 articles about 2-[(1R)-2-HYDROXY-1-METHYLETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

phthalic anhydride (85-44-9) + (R)-2-aminopropan-1-ol (35320-23-1) → (1'R)-N-(1'-hydroxyethyl-2'-methyl)-1H-isoindole-1,3(2H)-dione (73323-91-8)

Guidance literature:

With triethylamine; In toluene; for 20h; Reflux;

Reference yield:

phthalic anhydride (85-44-9) + (R)-2-aminopropan-1-ol (35320-23-1) → (1'R)-N-(1'-hydroxyethyl-2'-methyl)-1H-isoindole-1,3(2H)-dione (73323-91-8)

Guidance literature:

With triethylamine; In toluene; for 3h; Heating / reflux; Azeotropic water removal;

Reference yield: 98.0%

(1'R)-N-(1'-hydroxyethyl-2'-methyl)-1H-isoindole-1,3(2H)-dione (73323-91-8) + 4-chloro-phenol (106-48-9,82344-39-6) → (+)-(R)-2-phthalimido-1-(4-chlorophenoxy)propane (545376-11-2)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm021014d

upstream raw materials:

phthalic anhydride

(R)-2-aminopropan-1-ol

Downstream raw materials:

(R)-2-[2-(2,5-difluorophenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione

(-)-(R)-2-[2-(2,6-dimethylphenoxy)-1-methylethyl]-1H-isoindole-1,3(2H)-dione

(+)-(R)-2-phthalimido-1-(4-chlorophenoxy)propane

(R)-2-[2-(4-iodo-phenoxy)-1-methyl-ethyl]-isoindol-1,3-dione

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