3-BROMO-5-METHOXY BENZONITRILE

Base Information

• Chemical Name: 3-BROMO-5-METHOXY BENZONITRILE
• CAS No.: 867366-91-4
• Molecular Formula: C8H6BrNO
• Molecular Weight: 212.046
• Hs Code.: 2926909090
• Mol file: 867366-91-4.mol

Synonyms:3-Bromo-5-methoxybenzonitrile;

Chemical Property of 3-BROMO-5-METHOXY BENZONITRILE

Chemical Property:

• Boiling Point: 253.5 °C at 760 mmHg
• Flash Point: 107.1 °C
• PSA: 33.02000
• Density: 1.56 g/cm³
• LogP: 2.32938
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-5-methoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-BROMO-5-METHOXY BENZONITRILE

There total 8 articles about 3-BROMO-5-METHOXY BENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-bromo-5-methoxy-benzaldehyde oxime (867366-90-3) → 3-bromo-5-methoxybenzonitrile (867366-91-4)

Guidance literature:

With pyridine; trifluoroacetyl peroxide; In 1,4-dioxane; at 0 - 60 ℃; for 49h;

Reference yield:

zinc(II) cyanide (557-21-1) + 2-(3-bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (401797-04-4) → 3-bromo-5-methoxybenzonitrile (867366-91-4)

Guidance literature:

With copper(II) nitrate trihydrate; cesium fluoride; In methanol; water; at 100 ℃; for 6h;

DOI:10.1021/ja104442v

Reference yield:

(E)-1-(3-bromo-5-methoxyphenyl)-N-hydroxymethanimine → 3-bromo-5-methoxybenzonitrile (867366-91-4)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In 1,4-dioxane; at 0 - 60 ℃; for 49h;

upstream raw materials:

3-bromo-5-methoxy-benzaldehyde oxime

sodium methylate

3-bromo-5-fluorobenzonitrile

zinc(II) cyanide

Downstream raw materials:

3-bromo-5-hydroxybenzonitrile

3-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile

2-[(4-fluorobenzenesulfonyl)(isopropyl)amino]-N-(5-methoxy-4'-trifluoromethylbiphenyl-3-ylmethyl)acetamide

2-[ethyl-(4-fluorobenzenesulfonyl)amino]-N-(5-methoxy-4'-trifluoromethylbiphenyl-3-ylmethyl)acetamide

Refernces

• 1、 -. "NOVEL TETRADENTATE PLATINUM COMPLEXES". Page/Page column 128. . Retrieved 2012/09/11.
• 2、 -. "HETEROCYCLIC ANTIVIRAL COMPOUNDS". Page/Page column 23. . Retrieved 2009/07/17.