Technology Process of (2S,8S,E)-benzyl 8-(tert-butoxycarbonylamino)-2-(dibenzylamino)-7-oxonon-5-enoate
There total 2 articles about (2S,8S,E)-benzyl 8-(tert-butoxycarbonylamino)-2-(dibenzylamino)-7-oxonon-5-enoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
dimethyl (S)-3-[N-(tert-butoxycarbonyl)amino]-2-oxobutylphosphonate;
With
N-ethyl-N,N-diisopropylamine; lithium chloride;
In
acetonitrile;
at 20 ℃;
Inert atmosphere;
2-dibenzylamino-5-oxo-pentanoic acid benzyl ester;
In
acetonitrile;
at 20 ℃;
Inert atmosphere;
DOI:10.1002/ejoc.201101387
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
With
n-butyllithium; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
tetrahydrofuran; acetonitrile;
2.1: Horner-Wadsworth-Emmons olefination / 2.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1002/ejoc.201101387
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 20% palladium hydroxide on charcoal; hydrogen; acetic acid / methanol / 8 h / 20 °C / 4560.31 Torr / Microwave irradiation
2.1: sodium hydroxide / tetrahydrofuran; water / 1 h / -5 - 20 °C
3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere
4.1: triethylamine / water; acetonitrile / 1 h
5.1: 4-methyl-morpholine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere; solid phase reaction
5.2: 0.17 h / Inert atmosphere; solid phase reaction
With
4-methyl-morpholine; triethylsilane; 20% palladium hydroxide on charcoal; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.201101387
![dimethyl (S)-3-[N-(tert-butoxycarbonyl)amino]-2-oxobutylphosphonate](/Databaselist/images/loading.webp)
