Acetic acid (1R,2R,3R,4S)-3-[2-(3-hydroxy-2,2-dimethyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Base Information

Chemical Name:Acetic acid (1R,2R,3R,4S)-3-[2-(3-hydroxy-2,2-dimethyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester
CAS No.:1026575-81-4
Molecular Formula:C₂₁H₃₀O₄
Molecular Weight:346.467
Hs Code.:

Synonyms:Acetic acid (1R,2R,3R,4S)-3-[2-(3-hydroxy-2,2-dimethyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

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Chemical Property of Acetic acid (1R,2R,3R,4S)-3-[2-(3-hydroxy-2,2-dimethyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

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Technology Process of Acetic acid (1R,2R,3R,4S)-3-[2-(3-hydroxy-2,2-dimethyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

There total 5 articles about Acetic acid (1R,2R,3R,4S)-3-[2-(3-hydroxy-2,2-dimethyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Acetic acid (1R,2R,3R,4S)-3-(2-{3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2,2-dimethyl-propyl}-benzyl)-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

: 1026575-81-4
Acetic acid (1R,2R,3R,4S)-3-[2-(3-hydroxy-2,2-dimethyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃;
DOI:10.1021/jm00062a013

Reference yield:

: 404575-34-4
7-oxabicyclo<2.2.1>heptane tetrahydrofuranol

: 1026575-81-4
Acetic acid (1R,2R,3R,4S)-3-[2-(3-hydroxy-2,2-dimethyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: EtMgBr / tetrahydrofuran / 0 - 25 °C

2: H₂, AcOH / 20percent Pd(OH)2-C / 760 Torr

3: pyridine / 0 - 25 °C

4: n-Bu₄NF / tetrahydrofuran / 25 °C

With pyridine; ethylmagnesium bromide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; palladium hydroxide - carbon; In tetrahydrofuran;
DOI:10.1021/jm00062a013

Reference yield:

: C₁₉H₃₃BrMgOSi

: 1026575-81-4
Acetic acid (1R,2R,3R,4S)-3-[2-(3-hydroxy-2,2-dimethyl-propyl)-benzyl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: EtMgBr / tetrahydrofuran / 0 - 25 °C

2: H₂, AcOH / 20percent Pd(OH)2-C / 760 Torr

3: pyridine / 0 - 25 °C

4: n-Bu₄NF / tetrahydrofuran / 25 °C

With pyridine; ethylmagnesium bromide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; palladium hydroxide - carbon; In tetrahydrofuran;
DOI:10.1021/jm00062a013