3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide

Base Information

Chemical Name:3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide
CAS No.:911203-12-8
Molecular Formula:C₁₉H₂₃N₃O₄
Molecular Weight:357.409
Hs Code.:

Synonyms:3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide

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Chemical Property of 3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide

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Technology Process of 3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide

There total 6 articles about 3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.4%

: 911203-11-7
3-(5-tert-butyloxazol-4-yl)-2-hydroxyacrylic acid

: 65864-22-4
(S)-2-amino-3-phenylpropionamide hydrochloride

: 911203-12-8
3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1016/j.tet.2009.02.058

Reference yield:

: 1538-75-6
2,2-dimethylpropanoic anhydride

: 911203-12-8
3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -60 - -40 °C

2.2: -60 °C

3.1: manganese(IV) oxide / acetone / 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 4 - 20 °C

5.1: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 14 h / 0 - 20 °C

With hydrogenchloride; manganese(IV) oxide; lithium aluminium tetrahydride; water; benzotriazol-1-ol; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 930591-55-2
[5-(tert-butyl)oxazol-4-yl]methanol

: 911203-12-8
3-(5-tert-butyloxazol-4-yl)-N-((S)-1-carbamoyl-2-phenylethyl)-2-hydroxyacrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: manganese(IV) oxide / acetone / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 14 h / 4 - 20 °C

3: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 14 h / 0 - 20 °C

With hydrogenchloride; manganese(IV) oxide; water; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; acetone;