RAS INHIBITORY PEPTIDE

Base Information

• Chemical Name: RAS INHIBITORY PEPTIDE
• CAS No.: 159088-48-9
• Molecular Formula: C₅₃H₉₁N₁₉O₁₁
• Molecular Weight: 1170.43
• Mol file: 159088-48-9.mol

Synonyms:L-Arginine,N2-[N2-[N2-[1-[1-[N-[1-[1-(1-L-valyl-L-prolyl)-L-prolyl]-L-prolyl]-L-valyl]-L-prolyl]-L-prolyl]-L-arginyl]-L-arginyl]-;1: PN: JP2003248001 SEQID: 4 unclaimed sequence; 5: PN: JP2005168328 SEQID: 4unclaimed sequence; 5: PN: US6184205 SEQID: 5 unclaimed sequence

Chemical Property of RAS INHIBITORY PEPTIDE

Chemical Property:

• PKA: 3.31±0.10(Predicted)
• PSA: 466.97000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 1.92050
• Storage Temp.: −20°C

Purity/Quality:

98%Min ^*data from raw suppliers

Ras Inhibitory Peptide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.

Technology Process of RAS INHIBITORY PEPTIDE

There total 1 articles about RAS INHIBITORY PEPTIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + t-Boc-L-valine (13734-41-3) + Boc-Arg(Tos)-OH (13836-37-8) → H-VPPPVPPRRR-OH (159088-48-9)

Guidance literature:

Multistep reaction.;

DOI:10.1016/j.bmc.2006.11.002

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

t-Boc-L-valine

Boc-Arg(Tos)-OH

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 159088-48-9 RAS INHIBITORY PEPTIDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send