Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate

Base Information

• Chemical Name: Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate
• CAS No.: 64067-99-8
• Molecular Formula: C9H8ClN3O2
• Molecular Weight: 225.634
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70381515
• Nikkaji Number: J861.469E
• Wikidata: Q72473643

Synonyms:ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate;64067-99-8;MFCD03086230;IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID, 6-CHLORO-, ETHYL ESTER;6-chloroimidazo[1,2-b]pyridazine-2-carboxylic acid ethyl ester;SCHEMBL974916;DTXSID70381515;ETHYL6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE;AMY14137;AKOS015843538;PB15726;SY008388;TS-00564;BB 0259846;CS-0041937;FT-0626144;A847127;AN-584/43307929;J-521191;ethyl 6-chloroimidazo[1,2-b]pyridazin-2-carboxylate;Ethyl 6-chloroimidazo[1,2-b]pyridazin-2-ylcarboxylate

Chemical Property of Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate

Chemical Property:

• Appearance/Colour: Brown solid
• Melting Point: 155-158 °C
• Refractive Index: 1.648
• PKA: 0.17±0.30(Predicted)
• PSA: 56.49000
• Density: 1.476 g/cm³
• LogP: 1.55940
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 225.0305042
• Heavy Atom Count: 15
• Complexity: 252

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl 6-Chloroimidazo[1,2-b]pyridazine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CN2C(=N1)C=CC(=N2)Cl
• Uses: Anti-inflammatory agent Anti-inflammatory agent.

Technology Process of Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate

There total 2 articles about Ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

6-chloro-pyridazin-3-ylamine (5469-69-2) + ethyl Bromopyruvate (70-23-5) → ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate (64067-99-8)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; at 100 ℃; for 12h;

Reference yield:

→ ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate (64067-99-8)

Guidance literature:

Reference yield: 97.0%

para-nitrophenyl bromide (586-78-7) + ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate (64067-99-8) → ethyl 6-chloro-3-(4-nitrophenyl)imidazo[1,2-b]pyridazine-2-carboxylate (1220351-49-4)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In toluene; at 110 ℃; for 8h;

DOI:10.1002/ejoc.200900849

upstream raw materials:

6-chloro-pyridazin-3-ylamine

ethyl Bromopyruvate

Downstream raw materials:

6-chloroimidazo[1,2-b]pyridazine-2-carboxylic acid

6-chloroimidazolo[1,2-b]pyridazine-2-carboxamide

ethyl 6-(4-chlorophenyl)imidazo[1,2-b]pyridazine-2-carboxylate

ethyl 6-chloro-3-phenylimidazo[1,2-b]pyridazine-2-carboxylate

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