Dibenzyl-[(S)-1-((5S,6S)-4-methoxy-1,7-dioxa-spiro[4.4]non-3-en-6-yl)-ethyl]-amine

Base Information

• Chemical Name: Dibenzyl-[(S)-1-((5S,6S)-4-methoxy-1,7-dioxa-spiro[4.4]non-3-en-6-yl)-ethyl]-amine
• CAS No.: 185333-02-2
• Molecular Formula: C₂₄H₂₉NO₃
• Molecular Weight: 379.499

Synonyms:Dibenzyl-[(S)-1-((5S,6S)-4-methoxy-1,7-dioxa-spiro[4.4]non-3-en-6-yl)-ethyl]-amine

Chemical Property of Dibenzyl-[(S)-1-((5S,6S)-4-methoxy-1,7-dioxa-spiro[4.4]non-3-en-6-yl)-ethyl]-amine

Chemical Property:

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Technology Process of Dibenzyl-[(S)-1-((5S,6S)-4-methoxy-1,7-dioxa-spiro[4.4]non-3-en-6-yl)-ethyl]-amine

There total 1 articles about Dibenzyl-[(S)-1-((5S,6S)-4-methoxy-1,7-dioxa-spiro[4.4]non-3-en-6-yl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-((S)-1-Dibenzylamino-ethyl)-3-(1-methoxy-propa-1,2-dienyl)-tetrahydro-furan-3-ol → Dibenzyl-[(S)-1-((5S,6S)-4-methoxy-1,7-dioxa-spiro[4.4]non-3-en-6-yl)-ethyl]-amine (185333-02-2)

Guidance literature:

With tert-butoxide; In dimethyl sulfoxide; at 50 ℃; for 14h; Yield given;

DOI:10.1002/jlac.199619961209

Reference yield: 97.0%

Dibenzyl-[(S)-1-((5S,6S)-4-methoxy-1,7-dioxa-spiro[4.4]non-3-en-6-yl)-ethyl]-amine (185333-02-2) → (5S,6S)-6-((S)-1-Dibenzylamino-ethyl)-1,7-dioxa-spiro[4.4]nonan-4-one

Guidance literature:

With sulfuric acid; In tetrahydrofuran; for 3h; Heating;

DOI:10.1002/jlac.199619961209

Reference yield:

Dibenzyl-[(S)-1-((5S,6S)-4-methoxy-1,7-dioxa-spiro[4.4]non-3-en-6-yl)-ethyl]-amine (185333-02-2) → (4S,5S,6S)-6-((S)-1-Dibenzylamino-ethyl)-4-(1-methoxy-propa-1,2-dienyl)-1,7-dioxa-spiro[4.4]nonan-4-ol

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / 2 N H₂SO₄ / tetrahydrofuran / 3 h / Heating

2: n-BuLi / diethyl ether; hexane / 1.) -40 deg C, 5 min, 2.) -78 deg C, 2 h

With n-butyllithium; sulfuric acid; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1002/jlac.199619961209

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