(1-(3,4-dimethoxyphenyl)cyclopropyl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methanone

Base Information

Chemical Name:(1-(3,4-dimethoxyphenyl)cyclopropyl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methanone
CAS No.:1386350-37-3
Molecular Formula:C₂₄H₂₆O₅
Molecular Weight:394.467
Hs Code.:

Synonyms:(1-(3,4-dimethoxyphenyl)cyclopropyl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methanone

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Chemical Property of (1-(3,4-dimethoxyphenyl)cyclopropyl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methanone

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Technology Process of (1-(3,4-dimethoxyphenyl)cyclopropyl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methanone

There total 14 articles about (1-(3,4-dimethoxyphenyl)cyclopropyl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1386350-34-0
2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one

: 2181-42-2
trimethylsulphonium iodide

: 1386350-37-3
(1-(3,4-dimethoxyphenyl)cyclopropyl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methanone

Guidance literature:: trimethylsulphonium iodide; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 0.666667h; Inert atmosphere;

2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 91.0%

: 1386350-34-0
2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one

: 1774-47-6
trimethylsulfoxonium iodide

: 1386350-37-3
(1-(3,4-dimethoxyphenyl)cyclopropyl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methanone

Guidance literature:: trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 0.666667h;

2-(3,4-dimethoxyphenyl)-1-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)prop-2-en-1-one; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 1h;
DOI:10.1021/jm301488q

Reference yield:

: 1386351-25-2
5-(2-methylbut-3-yn-2-yloxy)-2-nitrophenol

: 1386350-37-3
(1-(3,4-dimethoxyphenyl)cyclopropyl)(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-diethylaniline / 130 °C

2.1: potassium carbonate / acetone / 55 - 60 °C

3.1: tin(II) chloride dihdyrate / ethanol / 1 h / Reflux

4.1: hydrogen bromide / water / 0.17 h / 0 °C

4.2: 65 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

5.2: 0.5 h / -78 - 20 °C

6.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

8.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.67 h / 20 °C

8.2: 1 h / 20 °C

With n-butyllithium; tin(II) chloride dihdyrate; hydrogen bromide; sodium hydride; potassium carbonate; Dess-Martin periodane; N,N-diethylaniline; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1021/jm301488q