4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine

Base Information

Chemical Name:4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine
CAS No.:335592-59-1
Molecular Formula:C₁₈H₂₁Cl₂N₃O₂
Molecular Weight:382.29
Hs Code.:

Synonyms:4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine

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Chemical Property of 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine

Chemical Property:

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Technology Process of 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine

There total 5 articles about 4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 335592-60-4
tert-butyl (2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-propan-2-yl)carbamate

: 5750-76-5
2,4,5-trichloropyrimidine

: 335592-59-1
4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine

Guidance literature:: In 1,2-dimethoxyethane;
DOI:10.1016/j.bmcl.2007.01.086

Reference yield:

: 214973-83-8
tert-butyl (2-(4-bromophenyl)propan-2-yl)carbamate

: 335592-59-1
4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / KOAc / Pd(dppf)2Cl₂ / tetrahydrofuran

2: 80 percent / 1,2-dimethoxy-ethane

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/j.bmcl.2007.01.086

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 335592-59-1
4-[4-(1-tert-butoxycarbonylamino-1-methylethyl)phenyl]-2,5-dichloropyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / toluene

2: 82 percent / KOAc / Pd(dppf)2Cl₂ / tetrahydrofuran

3: 80 percent / 1,2-dimethoxy-ethane

With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,2-dimethoxyethane; toluene;
DOI:10.1016/j.bmcl.2007.01.086