(4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane

Base Information

Chemical Name:(4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane
CAS No.:306281-52-7
Molecular Formula:C₅₄H₇₀O₁₀S₂
Molecular Weight:943.276
Hs Code.:

(4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane

Synonyms:(4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane

Suppliers and Price of (4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane

There total 14 articles about (4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 108-24-7
acetic anhydride

: 306281-51-6
(2R,3R)-6-(2-{(4R,5R)-5-[(R)-2-Benzyloxy-1-((4S,5R)-4,5-bis-benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-[1,3]dithian-2-yl)-2-methyl-1-phenyl-hexan-3-ol

: 306281-52-7
(4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane

Guidance literature:: With dmap; In pyridine; at 80 ℃; for 26h;
DOI:10.1021/jo000700m

Reference yield:

: 4039-82-1
Benzyl propargyl ether

: 306281-52-7
(4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyl lithium / tetrahydrofuran; hexane / 1.42 h / -78 °C

1.2: 84 percent / hexane; tetrahydrofuran / 1.03 h / -78 - 0 °C

2.1: 95 percent / LiI; glacial acetic acid / 1.5 h / 70 °C

3.1: 87 percent / Cu(I) (2-thiophenecarboxylate) / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

4.1: 94 percent / DIBAL-H / CH₂Cl₂ / -40 - -10 °C

6.1: (COCl)2; DMSO; NEt₃ / CH₂Cl₂ / 1.5 h / -78 °C

7.1: 15 mg

8.1: 86 percent / DMAP / pyridine / 26 h / 80 °C

With dmap; n-butyllithium; oxalyl dichloride; copper(I) thiophene-2-carboxylate; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; triethylamine; lithium iodide; In tetrahydrofuran; pyridine; 1-methyl-pyrrolidin-2-one; hexane; dichloromethane; 1.1: Metallation / 1.2: Substitution / 2.1: Addition / 3.1: Condensation / 4.1: Reduction / 6.1: Swern oxidation / 8.1: Acetylation;
DOI:10.1021/jo000700m

Reference yield:

: 138435-42-4
4-benzyloxybut-2-ynoic acid ethyl ester

: 306281-52-7
(4'R,5'R,1''R,2''R,3''R,4''S,5''R)-2-[4'-acetoxy-5'-methyl-6'-phenylhex-1'-yl]-2-[6''-benzyloxy-3'',4''-bis(benzyloxymethyl)-1'',2'',4'',5''-bis(di-O-isopropylidene)-3''-hydroxyhex-1''-yl][1,3]dithiane

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / LiI; glacial acetic acid / 1.5 h / 70 °C

2: 87 percent / Cu(I) (2-thiophenecarboxylate) / 1-methyl-pyrrolidin-2-one / 0 - 20 °C

3: 94 percent / DIBAL-H / CH₂Cl₂ / -40 - -10 °C

5: (COCl)2; DMSO; NEt₃ / CH₂Cl₂ / 1.5 h / -78 °C

6: 15 mg

7: 86 percent / DMAP / pyridine / 26 h / 80 °C

With dmap; oxalyl dichloride; copper(I) thiophene-2-carboxylate; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; triethylamine; lithium iodide; In pyridine; 1-methyl-pyrrolidin-2-one; dichloromethane; 1: Addition / 2: Condensation / 3: Reduction / 5: Swern oxidation / 7: Acetylation;
DOI:10.1021/jo000700m