2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-hydroxy-6-methyl-2-pyrimidinamine

Base Information

• Chemical Name: 2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-hydroxy-6-methyl-2-pyrimidinamine
• CAS No.: 224195-00-0
• Molecular Formula: C₁₄H₁₆IN₃O
• Molecular Weight: 369.205
• Mol file: 224195-00-0.mol

Synonyms:2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-hydroxy-6-methyl-2-pyrimidinamine

Chemical Property of 2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-hydroxy-6-methyl-2-pyrimidinamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-hydroxy-6-methyl-2-pyrimidinamine

There total 1 articles about 2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-hydroxy-6-methyl-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

ethyl acetoacetate (141-97-9) + 2-iodo-4-isopropylphenylguanidine → 2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-hydroxy-6-methyl-2-pyrimidinamine (224195-00-0)

Guidance literature:

With potassium carbonate; In ethanol; for 100h; Heating;

DOI:10.1021/jm980222w

Reference yield: 63.0%

2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-hydroxy-6-methyl-2-pyrimidinamine (224195-00-0) → 2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-chloro-6-methyl-2-pyrimidinamine

Guidance literature:

With trichlorophosphate; for 4h;

DOI:10.1021/jm980222w

Reference yield:

2-N-<2-iodo-4-(1-methylethyl)phenyl>-4-hydroxy-6-methyl-2-pyrimidinamine (224195-00-0) → N-(2-iodo-4-(1-methylethyl)phenyl)-N-ethyl-4-chloro-6-methyl-2-pyrimidinamine (169880-89-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / POCl₃ / 4 h

2: 70 percent / NaH / dimethylformamide / 24 h

With sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1021/jm980222w

upstream raw materials:

ethyl acetoacetate

Downstream raw materials:

N-(2-iodo-4-(1-methylethyl)phenyl)-N-ethyl-4-chloro-6-methyl-2-pyrimidinamine