S-[4-(3,3-dicyano-2-phenyl-3,3a-dihydroazulen-5-yl)phenyl]ethanethioate

Base Information

Chemical Name:S-[4-(3,3-dicyano-2-phenyl-3,3a-dihydroazulen-5-yl)phenyl]ethanethioate
CAS No.:1430198-71-2
Molecular Formula:C₂₆H₁₈N₂OS
Molecular Weight:406.508
Hs Code.:

Synonyms:S-[4-(3,3-dicyano-2-phenyl-3,3a-dihydroazulen-5-yl)phenyl]ethanethioate

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Chemical Property of S-[4-(3,3-dicyano-2-phenyl-3,3a-dihydroazulen-5-yl)phenyl]ethanethioate

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Technology Process of S-[4-(3,3-dicyano-2-phenyl-3,3a-dihydroazulen-5-yl)phenyl]ethanethioate

There total 8 articles about S-[4-(3,3-dicyano-2-phenyl-3,3a-dihydroazulen-5-yl)phenyl]ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 69746-43-6
1-iodo-4-thioacetylbenzene

: 1430198-76-7
2-phenyl-7-(trimethylstannyl)-1,8a-dihydroazulene-1,1-dicarbonitrile

: 1430198-71-2
S-[4-(3,3-dicyano-2-phenyl-3,3a-dihydroazulen-5-yl)phenyl]ethanethioate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane; In toluene; at 110 ℃; for 0.25h;
DOI:10.1021/jo400362u

Reference yield:

: 102780-13-2
2-phenyl-1,8a-dihydroazulene-1,1-dicarbonitrile

: 1430198-71-2
S-[4-(3,3-dicyano-2-phenyl-3,3a-dihydroazulen-5-yl)phenyl]ethanethioate

Guidance literature:: Multi-step reaction with 4 steps

1: bromine / dichloromethane / 1 h / -78 °C

2: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 2 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / benzene / 16 h / Inert atmosphere; Reflux

4: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane / toluene / 0.25 h / 110 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenyl-arsane; bromine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene; benzene; 4: |Stille Cross Coupling;
DOI:10.1021/jo400362u

Reference yield:

: 1173928-37-4
7-bromo-2-phenyl-1,8a-dihydroazulene-1,1-dicarbonitrile

: 1430198-71-2
S-[4-(3,3-dicyano-2-phenyl-3,3a-dihydroazulen-5-yl)phenyl]ethanethioate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / benzene / 16 h / Inert atmosphere; Reflux

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenyl-arsane / toluene / 0.25 h / 110 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenyl-arsane; In toluene; benzene; 2: |Stille Cross Coupling;
DOI:10.1021/jo400362u