2,2,2-Trichloro-N-[(1S,2S)-1-[(E)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide

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Chemical Name:2,2,2-Trichloro-N-[(1S,2S)-1-[(E)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide
CAS No.:264205-86-9
Molecular Formula:C₂₃H₃₂Cl₃NO₅
Molecular Weight:508.87
Hs Code.:

Synonyms:2,2,2-Trichloro-N-[(1S,2S)-1-[(E)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide

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Chemical Property of 2,2,2-Trichloro-N-[(1S,2S)-1-[(E)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide

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Technology Process of 2,2,2-Trichloro-N-[(1S,2S)-1-[(E)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide

There total 5 articles about 2,2,2-Trichloro-N-[(1S,2S)-1-[(E)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 264205-84-7
(4R,5S)-4-[(R)-2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-phenylselanyl-ethyl]-2-trichloromethyl-5-[2-(2,4,6-trimethyl-benzyloxy)-ethyl]-4,5-dihydro-oxazole

: 2,2,2-Trichloro-N-[(1S,2S)-1-[(Z)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide

: 264205-86-9
2,2,2-Trichloro-N-[(1S,2S)-1-[(E)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide

Guidance literature:: (4R,5S)-4-[(R)-2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-1-phenylselanyl-ethyl]-2-trichloromethyl-5-[2-(2,4,6-trimethyl-benzyloxy)-ethyl]-4,5-dihydro-oxazole; With water; pyridinium p-toluenesulfonate; In acetone; at 20 ℃;

With dihydrogen peroxide; In tetrahydrofuran; at 20 ℃; Further stages.;
DOI:10.1039/a909400h

Reference yield:

: 1585-16-6
2-chloromethyl-1,3,5-trimethylbenzene

: 264205-86-9
2,2,2-Trichloro-N-[(1S,2S)-1-[(E)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Bu₂SnO / toluene

1.2: Bu₄NBr / 80 °C

2.1: DBU / acetonitrile / -30 - -20 °C

3.1: 67 percent / methyl trichloroacetimidate; propylene oxide / acetonitrile / -30 - 0 °C

4.1: PPTS; H₂O / acetone / 20 °C

4.2: 75 percent / H₂O₂ / tetrahydrofuran / 20 °C

With water; pyridinium p-toluenesulfonate; di(n-butyl)tin oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; methyloxirane; methyl 2,2,2-trichloroacetimidate; In acetone; toluene; acetonitrile; 1.1: Metallation / 1.2: Substitution / 2.1: Substitution / 3.1: Substitution / 4.1: Hydrolysis / 4.2: Oxidation;
DOI:10.1039/a909400h

Reference yield:

: 211518-41-1
(Z)-(S)-6-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-hex-4-ene-1,3-diol

: 264205-86-9
2,2,2-Trichloro-N-[(1S,2S)-1-[(E)-2-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-vinyl]-2-hydroxy-4-(2,4,6-trimethyl-benzyloxy)-butyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Bu₂SnO / toluene

1.2: Bu₄NBr / 80 °C

2.1: DBU / acetonitrile / -30 - -20 °C

3.1: 67 percent / methyl trichloroacetimidate; propylene oxide / acetonitrile / -30 - 0 °C

4.1: PPTS; H₂O / acetone / 20 °C

4.2: 75 percent / H₂O₂ / tetrahydrofuran / 20 °C

With water; pyridinium p-toluenesulfonate; di(n-butyl)tin oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; methyloxirane; methyl 2,2,2-trichloroacetimidate; In acetone; toluene; acetonitrile; 1.1: Metallation / 1.2: Substitution / 2.1: Substitution / 3.1: Substitution / 4.1: Hydrolysis / 4.2: Oxidation;
DOI:10.1039/a909400h