(2S)-2-fluoro-2--3-phenylpropanoic acid

Base Information

Chemical Name:(2S)-2-fluoro-2--3-phenylpropanoic acid
CAS No.:160000-10-2
Molecular Formula:C₁₈H₁₈FNO₄
Molecular Weight:331.344
Hs Code.:

(2S)-2-fluoro-2-<N-methyl-N-(p-methoxyphenyl)carbonyl>-3-phenylpropanoic acid

Synonyms:(2S)-2-fluoro-2--3-phenylpropanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-fluoro-2--3-phenylpropanoic acid

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Technology Process of (2S)-2-fluoro-2--3-phenylpropanoic acid

There total 2 articles about (2S)-2-fluoro-2--3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 160000-09-9
(2R)-2-fluoro-2--3-phenylpropanol

: 160000-10-2
(2S)-2-fluoro-2--3-phenylpropanoic acid

Guidance literature:: With chromium(VI) oxide; sulfuric acid; In acetone; for 2h; Ambient temperature;
DOI:10.1016/0957-4166(94)80050-2

Reference yield:

: 160000-08-8
(2R)-2-benzyl-2-fluoro-3-(tert-butyldimethylsilyloxy)-N-methyl-N-(p-methoxyphenyl)propionamide

: 160000-10-2
(2S)-2-fluoro-2--3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

2: 80 percent / CrO₃, H₂SO₄ / acetone / 2 h / Ambient temperature

With chromium(VI) oxide; sulfuric acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; acetone;
DOI:10.1016/0957-4166(94)80050-2