(R,Z)-dimethyl 2-(3-(((4-((2,5-dioxoimidazolidin-4-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate

Base Information

Chemical Name:(R,Z)-dimethyl 2-(3-(((4-((2,5-dioxoimidazolidin-4-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate
CAS No.:1310744-70-7
Molecular Formula:C₂₅H₂₆N₄O₇
Molecular Weight:494.504
Hs Code.:

Synonyms:(R,Z)-dimethyl 2-(3-(((4-((2,5-dioxoimidazolidin-4-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate

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Chemical Property of (R,Z)-dimethyl 2-(3-(((4-((2,5-dioxoimidazolidin-4-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate

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Technology Process of (R,Z)-dimethyl 2-(3-(((4-((2,5-dioxoimidazolidin-4-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate

There total 5 articles about (R,Z)-dimethyl 2-(3-(((4-((2,5-dioxoimidazolidin-4-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: (Z)-5-(4-aminobenzylidene)imidazolidine-2,4-dione

: 1243277-30-6
(R)-dimethyl 2-(3-formylbenzamido)pentanedioate

: 1310744-70-7
(R,Z)-dimethyl 2-(3-(((4-((2,5-dioxoimidazolidin-4-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate

Guidance literature:: (Z)-5-(4-aminobenzylidene)imidazolidine-2,4-dione; (R)-dimethyl 2-(3-formylbenzamido)pentanedioate; With acetic acid; In methanol; at 65 ℃; for 1h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm2002525

Reference yield:

: 619-21-6
m-formylphenyl benzoic acid

: 1310744-70-7
(R,Z)-dimethyl 2-(3-(((4-((2,5-dioxoimidazolidin-4-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / dichloromethane / 0.25 h

1.2: 3 h / 20 °C

2.1: acetic acid / methanol / 1 h / 65 °C

2.2: 20 h / 20 °C / Inert atmosphere

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm2002525

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1310744-70-7
(R,Z)-dimethyl 2-(3-(((4-((2,5-dioxoimidazolidin-4-ylidene)methyl)phenyl)amino)methyl)benzamido)pentanedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate; acetic acid / 20 h / Reflux

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; N,N-dimethyl-formamide / 20 h / 20 °C

3.1: acetic acid / methanol / 1 h / 65 °C

3.2: 20 h / 20 °C / Inert atmosphere

With palladium 10% on activated carbon; ammonium acetate; hydrogen; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1.1: Knoevenagel condensation;
DOI:10.1021/jm2002525