(1R,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane-2-carboxylic acid

Base Information

• Chemical Name: (1R,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane-2-carboxylic acid
• CAS No.: 201669-72-9
• Molecular Formula: C₂₆H₂₂N₂O₂
• Molecular Weight: 394.473
• Mol file: 201669-72-9.mol

Synonyms:(1R,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane-2-carboxylic acid

Chemical Property of (1R,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane-2-carboxylic acid

There total 6 articles about (1R,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(1R,2R)-2-formyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane (250672-66-3) → (1R,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane-2-carboxylic acid (201669-72-9)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; In dichloromethane; water; acetone; at 20 ℃; for 12h;

DOI:10.1021/jm020415q

Reference yield:

((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-[(1R,2R)-2-(1-trityl-1H-imidazol-4-yl)-cyclopropyl]-methanone (201669-70-7) → (1R,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane-2-carboxylic acid (201669-72-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; Ambient temperature;

DOI:10.1016/S0960-894X(97)10137-8

Reference yield:

trityl chloride (76-83-5) → (1R,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane-2-carboxylic acid (201669-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / Et₃N / CHCl₃ / 12 h / Ambient temperature

2: 1.06 g / NaH / tetrahydrofuran; dimethylsulfoxide / rt 1 h, 60 deg C, 6 h

3: aq. LiOH / tetrahydrofuran / Ambient temperature

With lithium hydroxide; sodium hydride; triethylamine; In tetrahydrofuran; chloroform; dimethyl sulfoxide;

DOI:10.1016/S0960-894X(97)10137-8

upstream raw materials:

((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-[(1R,2R)-2-(1-trityl-1H-imidazol-4-yl)-cyclopropyl]-methanone

(1R,2R)-2-formyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

trityl chloride

(E)-1-((1S,5R,7R)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-(1H-imidazol-4-yl)-propenone

Downstream raw materials:

(1R,2R)-2-(t-butyloxycarbonylamino)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

(1S,2S)-2-(t-butyloxycarbonylamino)-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

(1S,2S)-2-azidocarbonyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

(1R,2R)-2-azidocarbonyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane