ethyl 2-[4-chloro-3-fluoro-6-(2-methyl-1,3-dioxolan-2-yl)-2-vinylphenoxy]propanoate

Base Information

Chemical Name:ethyl 2-[4-chloro-3-fluoro-6-(2-methyl-1,3-dioxolan-2-yl)-2-vinylphenoxy]propanoate
CAS No.:1462921-46-5
Molecular Formula:C₁₇H₂₀ClFO₅
Molecular Weight:358.794
Hs Code.:

Synonyms:ethyl 2-[4-chloro-3-fluoro-6-(2-methyl-1,3-dioxolan-2-yl)-2-vinylphenoxy]propanoate

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Chemical Property of ethyl 2-[4-chloro-3-fluoro-6-(2-methyl-1,3-dioxolan-2-yl)-2-vinylphenoxy]propanoate

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Technology Process of ethyl 2-[4-chloro-3-fluoro-6-(2-methyl-1,3-dioxolan-2-yl)-2-vinylphenoxy]propanoate

There total 5 articles about ethyl 2-[4-chloro-3-fluoro-6-(2-methyl-1,3-dioxolan-2-yl)-2-vinylphenoxy]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1462921-44-3
ethyl 2-[4-chloro-3-fluoro-2-iodo-6-(2-methyl-1,3-dioxolan-2-yl)phenoxy]propanoate

: 75927-49-0
pinacol vinylboronate

: 1462921-46-5
ethyl 2-[4-chloro-3-fluoro-6-(2-methyl-1,3-dioxolan-2-yl)-2-vinylphenoxy]propanoate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; dichloromethane; water; at 80 ℃; for 2h; Inert atmosphere;

Reference yield:

: 865451-01-0
1-(5-chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one

: 1462921-46-5
ethyl 2-[4-chloro-3-fluoro-6-(2-methyl-1,3-dioxolan-2-yl)-2-vinylphenoxy]propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodo-succinimide / acetic acid / 2 h / 70 °C

2: potassium carbonate / N,N-dimethyl-formamide / 60 - 90 °C

3: toluene-4-sulfonic acid / toluene / Reflux

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / dichloromethane; 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

With N-iodo-succinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;

Reference yield:

: 348-60-7
4-chloro-3-fluorophenol

: 1462921-46-5
ethyl 2-[4-chloro-3-fluoro-6-(2-methyl-1,3-dioxolan-2-yl)-2-vinylphenoxy]propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2 h / 60 °C / Inert atmosphere

1.2: 0.5 h / 180 °C

2.1: N-iodo-succinimide / acetic acid / 2 h / 70 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 60 - 90 °C

4.1: toluene-4-sulfonic acid / toluene / Reflux

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / dichloromethane; 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

With N-iodo-succinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;