Technology Process of (3-{[(16β,17β)-3-(aminomethyl)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide)
There total 10 articles about (3-{[(16β,17β)-3-(aminomethyl)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3-{[(16β,17β)-3-(bromomethyl)-17-hydroxyestra-1(10),2,4-trien-16-yl]methyl}benzamide);
With
sodium azide;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 3h;
Inert atmosphere;
With
hydrogen;
palladium 10% on activated carbon;
In
ethanol;
for 24h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide / ethanol; water / 0.5 h / Reflux
2.1: sodium tetrahydroborate; methanol / dichloromethane / 2 h / 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / Inert atmosphere
4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 5 h / 0 °C
6.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
6.2: 24 h / Inert atmosphere
With
methanol; sodium tetrahydroborate; sodium azide; carbon tetrabromide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
-
![(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid](/Databaselist/images/loading.webp)
-
2455-37-0
(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3-carboxylic acid
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium hydroxide / ethanol; water / 0.5 h / Reflux
2.1: sodium tetrahydroborate; methanol / dichloromethane / 2 h / 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethanol / 48 h / 20 °C / Inert atmosphere
4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium tetrahydroborate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere
5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 5 h / 0 °C
6.1: sodium azide / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
6.2: 24 h / Inert atmosphere
With
methanol; sodium tetrahydroborate; sodium azide; carbon tetrabromide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
