Diphenyl-acetic acid (3R,4R,5S,6R)-1-benzyl-4,5-bis-benzyloxy-6-formyl-piperidin-3-yl ester

Base Information

Chemical Name:Diphenyl-acetic acid (3R,4R,5S,6R)-1-benzyl-4,5-bis-benzyloxy-6-formyl-piperidin-3-yl ester
CAS No.:773080-71-0
Molecular Formula:C₄₁H₃₉NO₅
Molecular Weight:625.764
Hs Code.:

Synonyms:Diphenyl-acetic acid (3R,4R,5S,6R)-1-benzyl-4,5-bis-benzyloxy-6-formyl-piperidin-3-yl ester

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Chemical Property of Diphenyl-acetic acid (3R,4R,5S,6R)-1-benzyl-4,5-bis-benzyloxy-6-formyl-piperidin-3-yl ester

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Technology Process of Diphenyl-acetic acid (3R,4R,5S,6R)-1-benzyl-4,5-bis-benzyloxy-6-formyl-piperidin-3-yl ester

There total 4 articles about Diphenyl-acetic acid (3R,4R,5S,6R)-1-benzyl-4,5-bis-benzyloxy-6-formyl-piperidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Trifluoro-methanesulfonate2-((2R,3S,4R,5R)-1-benzyl-3,4-bis-benzyloxy-5-diphenylacetoxy-piperidin-2-yl)-3-methyl-thiazol-3-ium;

: 773080-71-0
Diphenyl-acetic acid (3R,4R,5S,6R)-1-benzyl-4,5-bis-benzyloxy-6-formyl-piperidin-3-yl ester

Guidance literature:: Trifluoro-methanesulfonate2-((2R,3S,4R,5R)-1-benzyl-3,4-bis-benzyloxy-5-diphenylacetoxy-piperidin-2-yl)-3-methyl-thiazol-3-ium;; With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.166667h;

With silver nitrate; In acetonitrile; at 20 ℃; for 0.0833333h;
DOI:10.1055/s-2004-829566

Reference yield:

: 117-34-0
2,2-diphenylacetic acid

: 773080-71-0
Diphenyl-acetic acid (3R,4R,5S,6R)-1-benzyl-4,5-bis-benzyloxy-6-formyl-piperidin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 74 percent / PPh₃; DIAD / tetrahydrofuran / 2 h / 80 °C

2.1: 4 Angstroem molecular sieves / acetonitrile / 0.25 h / 20 °C

3.1: NaBH₄ / methanol / 0.17 h / 20 °C

3.2: 30 mg / aq. AgNO₃ / acetonitrile / 0.08 h / 20 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; 4 A molecular sieve; triphenylphosphine; In tetrahydrofuran; methanol; acetonitrile; 1.1: Mitsunobu reaction;
DOI:10.1055/s-2004-829566

Reference yield:

: ((2S,3R,4S,5R)-1-Benzyl-3,4-bis-benzyloxy-5-thiazol-2-yl-pyrrolidin-2-yl)-methanol

: 773080-71-0
Diphenyl-acetic acid (3R,4R,5S,6R)-1-benzyl-4,5-bis-benzyloxy-6-formyl-piperidin-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 74 percent / PPh₃; DIAD / tetrahydrofuran / 2 h / 80 °C

2.1: 4 Angstroem molecular sieves / acetonitrile / 0.25 h / 20 °C

3.1: NaBH₄ / methanol / 0.17 h / 20 °C

3.2: 30 mg / aq. AgNO₃ / acetonitrile / 0.08 h / 20 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; 4 A molecular sieve; triphenylphosphine; In tetrahydrofuran; methanol; acetonitrile; 1.1: Mitsunobu reaction;
DOI:10.1055/s-2004-829566