<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanin

Base Information

• Chemical Name: <1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanin
• CAS No.: 73958-18-6
• Molecular Formula: C₂₅H₃₁N₃O₆
• Molecular Weight: 469.538
• Mol file: 73958-18-6.mol

Synonyms:<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanin

Chemical Property of <1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of <1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanin

There total 1 articles about <1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-alanyl-alanine methylester hydrochloride (41036-19-5,105328-90-3) → <1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanin (73958-18-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / NMM, DCCI / CH₂Cl₂ / 17 h / 0 °C

2: 96 percent / 1) 1 N NaOH / methanol / 0.83 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

DOI:10.1002/jlac.198019800105

Reference yield:

<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanin (73958-18-6) + (2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with 4-methyl-morpholine → 6-<<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>alanyl-alanyl-alanylamino>penicillansaeure (73974-11-5)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1) THF, 10 min, -15 deg C, 2) 50percent aqueous THF, 0 deg C, 2 h;

DOI:10.1002/jlac.198019800105

Reference yield:

<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanin (73958-18-6) + (6R,7R)-3-Acetoxymethyl-7-amino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; compound with 4-methyl-morpholine → 7-<<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanylamino>cephalosporansaeure (73974-13-7)

Guidance literature:

With 4-methyl-morpholine; isobutyl chloroformate; Yield given. Multistep reaction; 1) THF, 10 min, -20 to -15 deg C, 2) 50percent aqueous THF, 0 deg C, 2 h;

DOI:10.1002/jlac.198019800105

upstream raw materials:

L-alanyl-alanine methylester hydrochloride

Downstream raw materials:

6-<<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>alanyl-alanyl-alanylamino>penicillansaeure

7-<<1-(Biphenyl-4-yl)-1-methylethoxycarbonyl>-alanyl-alanyl-alanylamino>cephalosporansaeure