(S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methyl-4-[(triisopropylsilyl)ethynyl]pyridine

Base Information

Chemical Name:(S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methyl-4-[(triisopropylsilyl)ethynyl]pyridine
CAS No.:1352743-31-7
Molecular Formula:C₃₂H₅₁NOSi₂
Molecular Weight:521.934
Hs Code.:

Synonyms:(S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methyl-4-[(triisopropylsilyl)ethynyl]pyridine

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Chemical Property of (S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methyl-4-[(triisopropylsilyl)ethynyl]pyridine

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Technology Process of (S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methyl-4-[(triisopropylsilyl)ethynyl]pyridine

There total 6 articles about (S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methyl-4-[(triisopropylsilyl)ethynyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1352743-26-0
C₂₅H₃₀F₉NO₄SSi

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1352743-31-7
(S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methyl-4-[(triisopropylsilyl)ethynyl]pyridine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 60 ℃; for 16h; Inert atmosphere;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-08-8
(S,Z)-2-(tert-butyldimethylsiloxy)-N-(5-oxohept-3-en-3-yl)-2-phenylacetamide

: 1352743-31-7
(S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methyl-4-[(triisopropylsilyl)ethynyl]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylsilyl trifluoromethanesulfonate; triethylamine / dichloromethane / 48 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 16 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 16 h / 60 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil; 3.1: Sonogashira coupling;
DOI:10.1002/ejoc.201100681

Reference yield:

: 1352743-17-9
(S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methylpyridin-4(1H)-one

: 1352743-31-7
(S)-2-[(tert-butyldimethylsiloxy)(phenyl)methyl]-6-ethyl-3-methyl-4-[(triisopropylsilyl)ethynyl]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 16 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 16 h / 60 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium hydride; triethylamine; In tetrahydrofuran; mineral oil; 2.1: Sonogashira coupling;
DOI:10.1002/ejoc.201100681