4-(aminomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:4-(aminomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide
CAS No.:1429242-21-6
Molecular Formula:C₂₂H₂₂Cl₃N₅O
Molecular Weight:478.809
Hs Code.:

Synonyms:4-(aminomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of 4-(aminomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

Chemical Property:

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Technology Process of 4-(aminomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

There total 6 articles about 4-(aminomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₀Cl₃N₇O

: 1429242-21-6
4-(aminomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; water; at 20 ℃; for 16h;

Reference yield:

: 917081-44-8
ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-(hydroxymethyl)-1H-pyrazole-3-carboxylate

: 1429242-21-6
4-(aminomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 20 °C / Inert atmosphere

2: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

4: triphenylphosphine / tetrahydrofuran; water / 16 h / 20 °C

With aluminum (III) chloride; sodium azide; phosphorus tribromide; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 168272-91-1
ethyl 4-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate

: 1429242-21-6
4-(aminomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: silver nitrate; water / acetone / 60 °C

2: aluminum (III) chloride / 1,2-dichloro-ethane / 16 h / 0 - 20 °C / Inert atmosphere

3: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

4: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

5: triphenylphosphine / tetrahydrofuran; water / 16 h / 20 °C

With aluminum (III) chloride; sodium azide; water; phosphorus tribromide; silver nitrate; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;