3-(3-iodo-4-isopropoxyphenyl)-5-(4-propoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(3-iodo-4-isopropoxyphenyl)-5-(4-propoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole
CAS No.:1608147-45-0
Molecular Formula:C₂₁H₂₀F₃IN₂O₃
Molecular Weight:532.301
Hs Code.:

Synonyms:3-(3-iodo-4-isopropoxyphenyl)-5-(4-propoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

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Chemical Property of 3-(3-iodo-4-isopropoxyphenyl)-5-(4-propoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

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Technology Process of 3-(3-iodo-4-isopropoxyphenyl)-5-(4-propoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

There total 6 articles about 3-(3-iodo-4-isopropoxyphenyl)-5-(4-propoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1220973-38-5
N-hydroxy-3-iodo-4-isopropoxybenzimidamide

: 213598-18-6
4-propoxy-3-(trifluoromethyl)benzoic acid

: 1608147-45-0
3-(3-iodo-4-isopropoxyphenyl)-5-(4-propoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

Guidance literature:: N-hydroxy-3-iodo-4-isopropoxybenzimidamide; 4-propoxy-3-(trifluoromethyl)benzoic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; at 45 ℃; for 0.25h; Inert atmosphere;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 120 ℃; for 2h; Inert atmosphere;

Reference yield:

: 15126-06-4
methyl 3-iodo-4-hydroxybenzoate

: 1608147-45-0
3-(3-iodo-4-isopropoxyphenyl)-5-(4-propoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 55 °C / Inert atmosphere

2.1: copper(l) iodide / N,N-dimethyl-formamide / 6 h / 70 - 90 °C / Inert atmosphere

3.1: potassium hydroxide; water / 1,4-dioxane / 0.08 h / Reflux

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 0.25 h / 45 °C / Inert atmosphere

4.2: 2 h / 120 °C / Inert atmosphere

With copper(l) iodide; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1131614-13-5
methyl 3-iodo-4-propoxybenzoate

: 1608147-45-0
3-(3-iodo-4-isopropoxyphenyl)-5-(4-propoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide / N,N-dimethyl-formamide / 6 h / 70 - 90 °C / Inert atmosphere

2.1: potassium hydroxide; water / 1,4-dioxane / 0.08 h / Reflux

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide / 0.25 h / 45 °C / Inert atmosphere

3.2: 2 h / 120 °C / Inert atmosphere

With copper(l) iodide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide;