2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-4-hydroxy-phenyl ester

Base Information

• Chemical Name: 2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-4-hydroxy-phenyl ester
• CAS No.: 210840-43-0
• Molecular Formula: C₂₆H₃₅NO₅
• Molecular Weight: 441.568

Synonyms:2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-4-hydroxy-phenyl ester

Chemical Property of 2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-4-hydroxy-phenyl ester

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Technology Process of 2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-4-hydroxy-phenyl ester

There total 3 articles about 2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-4-hydroxy-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-Benzyloxycarbonylamino-2-methyl-propionic acid 1,3,5-tri-tert-butyl-4-oxo-cyclohexa-2,5-dienyl ester → 2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-4-hydroxy-phenyl ester (210840-43-0) + 2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-2-hydroxy-phenyl ester

Guidance literature:

With Amberlyst 15; hydrogen cation; In toluene; at -20 - -10 ℃;

DOI:10.1016/S0040-4020(01)87054-X

Reference yield:

2,4,6-tri-tert-butylphenoxol (732-26-3) → 2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-4-hydroxy-phenyl ester (210840-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent Turnov_. / 2,6-lutidine, Et₄NBF₄ / CH₂Cl₂ / anodic oxidation (+1100 mV)

2: 69 percent / Amberlyst 15/H+ / toluene / -15 - -5 °C

With 2,6-dimethylpyridine; Amberlyst 15; hydrogen cation; N,N,N,N-tetraethylammonium tetrafluoroborate; In dichloromethane; toluene;

DOI:10.1016/S0040-4020(01)87054-X

Reference yield:

Z-Aib-OH (15030-72-5) → 2-Benzyloxycarbonylamino-2-methyl-propionic acid 3,5-di-tert-butyl-4-hydroxy-phenyl ester (210840-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent Turnov_. / 2,6-lutidine, Et₄NBF₄ / CH₂Cl₂ / anodic oxidation (+1100 mV)

2: 69 percent / Amberlyst 15/H+ / toluene / -15 - -5 °C

With 2,6-dimethylpyridine; Amberlyst 15; hydrogen cation; N,N,N,N-tetraethylammonium tetrafluoroborate; In dichloromethane; toluene;

DOI:10.1016/S0040-4020(01)87054-X

upstream raw materials:

2,4,6-tri-tert-butylphenoxol

Z-Aib-OH

Downstream raw materials:

methyl (2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-valinate

methyl N-(2-(((benzyloxy)carbonyl)amino)-2-methylpropanoyl)-L-alaninate

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