(2S,3S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(p-tolyl)-2,3-dihydro-1H-inden-1-one

Base Information

Chemical Name:(2S,3S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(p-tolyl)-2,3-dihydro-1H-inden-1-one
CAS No.:1319024-97-9
Molecular Formula:C₂₆H₂₆O₅
Molecular Weight:418.489
Hs Code.:

Synonyms:(2S,3S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(p-tolyl)-2,3-dihydro-1H-inden-1-one

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Chemical Property of (2S,3S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(p-tolyl)-2,3-dihydro-1H-inden-1-one

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Technology Process of (2S,3S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(p-tolyl)-2,3-dihydro-1H-inden-1-one

There total 5 articles about (2S,3S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(p-tolyl)-2,3-dihydro-1H-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 106-38-7
para-bromotoluene

: 1319024-91-3
(S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2,3-dihydro-1H-inden-1-one

: 1319024-97-9
(2S,3S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(p-tolyl)-2,3-dihydro-1H-inden-1-one

Guidance literature:: With palladium diacetate; sodium t-butanolate; XPhos; In tetrahydrofuran; at 80 ℃; for 3h; diastereoselective reaction;
DOI:10.1021/jo2009164

Reference yield:

: 1319024-90-2
3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-1H-inden-1-one

: 1319024-97-9
(2S,3S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(p-tolyl)-2,3-dihydro-1H-inden-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: baker's yeast; alpha-D-glucopyranose; sodium hydroxide / dimethyl sulfoxide / 48 h / 40 °C / pH 7.2 / aq. phosphate buffer; Enzymatic reaction

2: palladium diacetate; sodium t-butanolate; XPhos / tetrahydrofuran / 3 h / 80 °C

With alpha-D-glucopyranose; baker's yeast; palladium diacetate; sodium hydroxide; sodium t-butanolate; XPhos; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jo2009164

Reference yield:

: 1319024-88-8
(E)-1-(2-bromo-3,5-dimethoxyphenyl)-3-(3,5-dimethoxyphenyl)prop-2-en-1-one

: 1319024-97-9
(2S,3S)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(p-tolyl)-2,3-dihydro-1H-inden-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; triphenylphosphine; palladium dichloride / N,N-dimethyl-formamide / 1 h / 140 °C

2: baker's yeast; alpha-D-glucopyranose; sodium hydroxide / dimethyl sulfoxide / 48 h / 40 °C / pH 7.2 / aq. phosphate buffer; Enzymatic reaction

3: palladium diacetate; sodium t-butanolate; XPhos / tetrahydrofuran / 3 h / 80 °C

With alpha-D-glucopyranose; baker's yeast; palladium diacetate; potassium carbonate; triphenylphosphine; sodium hydroxide; palladium dichloride; sodium t-butanolate; XPhos; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Heck reaction;
DOI:10.1021/jo2009164