2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid

Base Information

Chemical Name:2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid
CAS No.:122622-74-6
Molecular Formula:C₂₂H₂₅N₇O₅
Molecular Weight:467.484
Hs Code.:

Synonyms:2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid

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Chemical Property of 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid

Chemical Property:

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Technology Process of 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid

There total 6 articles about 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 122594-34-7
9-ethyl-10-deazaminopterin diethyl ester

: 122622-74-6
2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid

Guidance literature:: With sodium hydroxide; In 2-methoxy-ethanol;
DOI:10.1021/jm00163a035

Reference yield:

: 122594-21-2
4-(4-Chloro-2-ethyl-3-oxo-butyl)-benzoic acid methyl ester

: 122622-74-6
2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / NaN₃ / methanol; H₂O

2: 44 percent / H₂, conc. HCl / Pd / ethanol

3: 67 percent / s-collidine / methanol; dimethylformamide

4: 1.) Zn, HOAc, 2.) H₂O₂

5: 54 percent / 10percent NaOH / 2-methoxy-ethanol

6: Et₃N, isobutyl chloroformate

7: 42 percent / 1N NaOH / 2-methoxy-ethanol

With 2,4,6-trimethyl-pyridine; hydrogenchloride; sodium hydroxide; sodium azide; hydrogen; dihydrogen peroxide; acetic acid; triethylamine; zinc; isobutyl chloroformate; palladium; In methanol; ethanol; 2-methoxy-ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a035

Reference yield:

: 122594-23-4
4-(4-Azido-2-ethyl-3-oxo-butyl)-benzoic acid methyl ester

: 122622-74-6
2-{4-[2-(2,4-Diamino-pteridin-6-yl)-butyl]-benzoylamino}-pentanedioic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 44 percent / H₂, conc. HCl / Pd / ethanol

2: 67 percent / s-collidine / methanol; dimethylformamide

3: 1.) Zn, HOAc, 2.) H₂O₂

4: 54 percent / 10percent NaOH / 2-methoxy-ethanol

5: Et₃N, isobutyl chloroformate

6: 42 percent / 1N NaOH / 2-methoxy-ethanol

With 2,4,6-trimethyl-pyridine; hydrogenchloride; sodium hydroxide; hydrogen; dihydrogen peroxide; acetic acid; triethylamine; zinc; isobutyl chloroformate; palladium; In methanol; ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a035