1-benzhydrylazetidin-3-ol Hydrochloride

Base Information

• Chemical Name: 1-benzhydrylazetidin-3-ol Hydrochloride
• CAS No.: 90604-02-7
• Molecular Formula: C16H18NOCl
• Molecular Weight: 275.778
• Hs Code.: 2933990090
• European Community (EC) Number: 675-289-5
• DSSTox Substance ID: DTXSID60384318
• Mol file: 90604-02-7.mol

Synonyms:90604-02-7;1-benzhydrylazetidin-3-ol Hydrochloride;1-(Diphenylmethyl)-3-hydroxyazetidine hydrochloride;1-benzhydryl-3-azetidinol hydrochloride;1-(diphenylmethyl)azetidin-3-ol hydrochloride;1-(diphenylmethyl)-3-azetidinol hydrochloride;MFCD00209447;3-Azetidinol, 1-(diphenylmethyl)-, hydrochloride;1-benzhydrylazetidin-3-ol;hydrochloride;1-Benzhydryl-azetidin-3-ol hydrochloride;1-benzhydrylazetidin-3-ol hcl;1-(Diphenylmethyl)-3-hydroxyazetidine, HCl;N-Benzhydrylazetidin-3-ol hydrochloride;1-(Diphenylmethyl)-3-hydroxyazetidine HCl;1-diphenylmethyl-3-hydroxy-azetidine hydrochloride;SCHEMBL741583;1-Benzhydryl-3-azetidinol HCl;DTXSID60384318;LCHTWRWPHBRTNO-UHFFFAOYSA-N;BCP22027;1-benzhydrylazetidin-3-olhydrochloride;AKOS005256298;CL-0701;CS-W002514;PS-7252;1-Diphenylmethyl-3-Hydroxyazetidine HCl;SY002561;AM20041373;FT-0648213;N-Diphenylmethyl-3-hydroxyazetidine hydrochloride;1-(diphenylmethyl)azetidin-3-ol hydrochloric acid;1-(diphenylmethyl)azetidin-3-ol hydrochloride salt;Q-103147;3-Azetidinol, 1-(diphenylmethyl)-hydrochloride (1:1);1-BENZHYDRYLAZETIDIN-3-OL HCL

Chemical Property of 1-benzhydrylazetidin-3-ol Hydrochloride

Chemical Property:

• Vapor Pressure: 1.29E-05mmHg at 25°C
• Melting Point: 172-174 °C
• Boiling Point: 353.8 °C at 760 mmHg
• Flash Point: 101.7 °C
• PSA: 23.47000
• LogP: 3.19240
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly, Heated), Methanol (Sli
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 275.1076919
• Heavy Atom Count: 19
• Complexity: 232

Purity/Quality:

99% ^*data from raw suppliers

1-(Diphenylmethyl)-3-hydroxyazetidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(CN1C(C2=CC=CC=C2)C3=CC=CC=C3)O.Cl

Technology Process of 1-benzhydrylazetidin-3-ol Hydrochloride

There total 7 articles about 1-benzhydrylazetidin-3-ol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(diphenylmethyl)-3-hydroxyazetidine (18621-17-5) → 1-(diphenylmethyl)-3-azetidinol hydrochloride (90604-02-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.166667h;

Reference yield: 51.0%

Benzhydrylamine (91-00-9) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-(diphenylmethyl)-3-azetidinol hydrochloride (90604-02-7)

Guidance literature:

Reference yield: 51.0%

aminodiphenylmethane hydrochloride (5267-34-5) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-(diphenylmethyl)-3-azetidinol hydrochloride (90604-02-7)

Guidance literature:

aminodiphenylmethane hydrochloride; With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 12h;

epichlorohydrin; In methanol; at 20 ℃; for 72h;

DOI:10.1246/cl.1999.605

upstream raw materials:

Benzhydrylamine

epichlorohydrin

aminodiphenylmethane hydrochloride

3-chloro-1-diphenylmethylamino-2-hydroxypropane

Downstream raw materials:

N-benzhydryl 3-azetidinone

1-(diphenylmethyl)-3-methoxyazetidine

1-(Diphenylmethyl)-3-azetidinol methanesulfonate (ester) hydrochloride

1-benzhydryl-3-(tert-butyl-diphenyl-silanyloxy)-azetidine