2,6-difluoro-N-(3-((2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)acetyl)phenyl)benzamide

Base Information

Chemical Name:2,6-difluoro-N-(3-((2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)acetyl)phenyl)benzamide
CAS No.:1160622-83-2
Molecular Formula:C₃₀H₂₂F₅N₅O₃
Molecular Weight:595.528
Hs Code.:

Synonyms:2,6-difluoro-N-(3-((2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)acetyl)phenyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-difluoro-N-(3-((2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)acetyl)phenyl)benzamide

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2,6-difluoro-N-(3-((2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)acetyl)phenyl)benzamide

There total 1 articles about 2,6-difluoro-N-(3-((2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)acetyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1160622-82-1
N-(3-((2-chloro-4-pyrimidinyl)acetyl)phenyl)-2,6-difluorobenzamide

: 181634-14-0
1-(7-amino-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one

: 1160622-83-2
2,6-difluoro-N-(3-((2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)acetyl)phenyl)benzamide

Guidance literature:: N-(3-((2-chloro-4-pyrimidinyl)acetyl)phenyl)-2,6-difluorobenzamide; 1-(7-amino-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one; With hydrogenchloride; In N,N-dimethyl acetamide; water; isopropyl alcohol; at 70 ℃; for 15h;

With water; sodium hydrogencarbonate; In N,N-dimethyl acetamide; isopropyl alcohol;

Reference yield:

: 1160622-83-2
2,6-difluoro-N-(3-((2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)acetyl)phenyl)benzamide

: C₃₀H₂₁BrF₅N₅O₃

Guidance literature:: 2,6-difluoro-N-(3-((2-((2-(trifluoroacetyl)-1,2,3,4-tetrahydro-7-isoquinolinyl)amino)-4-pyrimidinyl)acetyl)phenyl)benzamide; With bromine; acetic acid; at 20 ℃; for 0.25h;

With sodium hydroxide; water;