Technology Process of N-((3R,5R)-6-((tert-butyldiphenylsilyl)oxy)-2,5-dimethyl-hexan-3-yl)acetamide
There total 7 articles about N-((3R,5R)-6-((tert-butyldiphenylsilyl)oxy)-2,5-dimethyl-hexan-3-yl)acetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
In
dichloromethane;
at 25 ℃;
for 16h;
under 37503.8 Torr;
optical yield given as %de;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/jo201215c
- Guidance literature:
-
With
(η4-1,5-cyclooctadiene)(1-[(4S)-(2-(1-adamantyl)-4,5-dihydrooxazolyl)ethyl]-3-(2,6-diisopropylphenyl)-4,5-dihydroimidazolin-2-ylidene)iridium(I) tetrakis(3,5-bis(trifluoromethyl)phenyl)borate; hydrogen;
In
dichloromethane;
at 25 ℃;
for 16h;
under 37503.8 Torr;
Reagent/catalyst;
diastereoselective reaction;
DOI:10.1021/jo4013783
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisobutylaluminium hydride / hexane; dichloromethane / 5 h / -50 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: 1H-imidazole / dichloromethane / 24 h / 25 °C
4.1: pyridine / dichloromethane / 1 h / 25 °C / Inert atmosphere
5.1: hydrogen / dichloromethane / 16 h / 25 °C / 37503.8 Torr / Inert atmosphere
With
pyridine; 1H-imidazole; hydrogen; diisobutylaluminium hydride; trifluoroacetic acid;
In
hexane; dichloromethane;
DOI:10.1021/jo201215c
