3-Fluoro-2-hydroxy-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester

Base Information

• Chemical Name: 3-Fluoro-2-hydroxy-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester
• CAS No.: 139161-82-3
• Molecular Formula: C₂₂H₁₀F₆N₂O₄
• Molecular Weight: 480.323

Synonyms:3-Fluoro-2-hydroxy-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester

Chemical Property of 3-Fluoro-2-hydroxy-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester

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Technology Process of 3-Fluoro-2-hydroxy-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester

There total 2 articles about 3-Fluoro-2-hydroxy-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-(2,3,4,5,6-pentafluorophenyl)-3-fluoro-2-hydroxy-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid ethyl ester (139161-81-2) + benzyl alcohol (100-51-6,185532-71-2) → 3-Fluoro-2-hydroxy-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester (139161-82-3)

Guidance literature:

With titanium(IV) tetraethanolate; at 100 ℃; for 2.5h;

DOI:10.1021/jm960207w

Reference yield:

→ 3-Fluoro-2-hydroxy-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester (139161-82-3)

Guidance literature:

Reference yield:

tert-butylpyrrolidin-2-ylcarbamate (185693-00-9) + 3-Fluoro-2-hydroxy-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester (139161-82-3) → 2-(3-(N-t-Butoxycarbonyl)aminopyrrolidin-1-yl)-3-fluoro-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester (139161-83-4)

Guidance literature:

With trichlorophosphate; In dichloromethane; triethylamine; N,N-dimethyl-formamide;

upstream raw materials:

9-(2,3,4,5,6-pentafluorophenyl)-3-fluoro-2-hydroxy-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid ethyl ester

benzyl alcohol

Downstream raw materials:

2-(3-(N-t-Butoxycarbonyl)aminopyrrolidin-1-yl)-3-fluoro-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid

2-(3-(N-t-Butoxycarbonyl)aminopyrrolidin-1-yl)-3-fluoro-9-(2,3,4,5,6-pentafluorophenyl)-6H-6-oxopyrido[1,2-a]pyrimidine-7-carboxylic acid benzyl ester

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