[1,4']Bipiperidinyl-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: [1,4']Bipiperidinyl-3-carboxylic acid ethyl ester
• CAS No.: 340962-71-2
• Molecular Formula: C13H24N2O2
• Molecular Weight: 240.34
• Hs Code.: 2933399090
• Mol file: 340962-71-2.mol

Synonyms:4-[3-(Ethoxycarbonyl)piperidino]piperidine;[1,4'-Bipiperidine]-3-carboxylic acid, ethyl ester;

Chemical Property of [1,4']Bipiperidinyl-3-carboxylic acid ethyl ester

Chemical Property:

• Boiling Point: 327.4 °C at 760 mmHg
• PKA: 10.31±0.10(Predicted)
• Flash Point: 151.8 °C
• PSA: 41.57000
• Density: 1.055 g/cm³
• LogP: 1.28020
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

Ethyl 1-(piperidin-4-yl)piperidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1,4']Bipiperidinyl-3-carboxylic acid ethyl ester

There total 5 articles about [1,4']Bipiperidinyl-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1'-tert-butyl 3-ethyl 1,4'-bipiperidine-1',3-dicarboxylate (433981-21-6) → [1,4']bipiperidinyl-3-carboxylic acid ethyl ester (340962-71-2)

Guidance literature:

With hydrogenchloride; water; In dichloromethane; for 18h;

Reference yield:

Ethyl 1'-benzyl-1,4'-bipiperidine-3-carboxylate (340962-86-9) → [1,4']bipiperidinyl-3-carboxylic acid ethyl ester (340962-71-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(00)00702-2

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → [1,4']bipiperidinyl-3-carboxylic acid ethyl ester (340962-71-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaCNBH₃; CF₃CH₂OH; 3A sieves

2: H₂ / Pd/C / methanol

With 2,2,2-trifluoroethanol; 3 A molecular sieve; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In methanol;

DOI:10.1016/S0960-894X(00)00702-2

upstream raw materials:

Ethyl 1'-benzyl-1,4'-bipiperidine-3-carboxylate

1-phenylmethyl-4-piperidone

Ethyl nipecotate

1'-tert-butyl 3-ethyl 1,4'-bipiperidine-1',3-dicarboxylate

Downstream raw materials:

3-methyl-2-phenylquinoline-4-carbonyl chloride

Refernces

• 1、 -. "PYRIMIDINE DERIVATIVES". Page/Page column 33. . Retrieved 2010/02/14.