N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide

Base Information

Chemical Name:N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide
CAS No.:1026502-55-5
Molecular Formula:C₃₃H₃₈FN₅O₄S
Molecular Weight:619.76
Hs Code.:

Synonyms:N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide

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Chemical Property of N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide

There total 12 articles about N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 462-08-8
pyridin-3-ylamine

: 1026502-55-5
N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 2.31 g / Et₃N / tetrahydrofuran / 48 h / Heating

2: 1.83 g / Et₃N / tetrahydrofuran / 3 h / Heating

3: 50 percent / aq. Na₂CO₃, (PPh₃)4Pd, tetrabutylammonium bromide / toluene / 4.5 h / Heating

4: 4.6 g / TFA / 12 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; toluene;
DOI:10.1021/jm00015a016

Reference yield:

: 51436-99-8
2-fluoro-4-bromotoluene

: 1026502-55-5
N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide

Guidance literature:: Multi-step reaction with 8 steps

1: NBS, AIBN / CCl₄ / 4 h / Heating

2: K₂CO₃ / dimethylformamide / 12 h / Ambient temperature

3: tetrahydrofuran / 1 h / Ambient temperature

4: MnO₂ / CH₂Cl₂ / Ambient temperature

5: 2.31 g / Et₃N / tetrahydrofuran / 48 h / Heating

6: 1.83 g / Et₃N / tetrahydrofuran / 3 h / Heating

7: 50 percent / aq. Na₂CO₃, (PPh₃)4Pd, tetrabutylammonium bromide / toluene / 4.5 h / Heating

8: 4.6 g / TFA / 12 h

With manganese(IV) oxide; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); tetrabutylammomium bromide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00015a016

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1026502-55-5
N-{3-[5-Ethyl-3-(3-fluoro-2'-sulfamoyl-biphenyl-4-ylmethyl)-2-propyl-3H-imidazol-4-yl]-3-oxo-propyl}-N-pyridin-3-yl-butyramide

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / dimethylformamide / 12 h / Ambient temperature

2: tetrahydrofuran / 1 h / Ambient temperature

3: MnO₂ / CH₂Cl₂ / Ambient temperature

4: 2.31 g / Et₃N / tetrahydrofuran / 48 h / Heating

5: 1.83 g / Et₃N / tetrahydrofuran / 3 h / Heating

6: 50 percent / aq. Na₂CO₃, (PPh₃)4Pd, tetrabutylammonium bromide / toluene / 4.5 h / Heating

7: 4.6 g / TFA / 12 h

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00015a016