5-CHLOROMETHYL-2-TRITYL-2H-TETRAZOLE

Base Information

• Chemical Name: 5-CHLOROMETHYL-2-TRITYL-2H-TETRAZOLE
• CAS No.: 160998-59-4
• Molecular Formula: C21H17 Cl N4
• Molecular Weight: 360.846
• Mol file: 160998-59-4.mol

Synonyms:5-Chloromethyl-2-(triphenylmethyl)-2H-tetrazole

Chemical Property of 5-CHLOROMETHYL-2-TRITYL-2H-TETRAZOLE

Chemical Property:

• Boiling Point: 540.9±60.0 °C(Predicted)
• PKA: -0.10±0.12(Predicted)
• PSA: 43.60000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 4.25210

Purity/Quality:

98%min ^*data from raw suppliers

5-(Chloromethyl)-2-trityl-2H-tetrazole 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloromethyl-2-(triphenylmethyl)-2H-tetrazole is used as a reactant in the preparation of carbazole derivatives as selective β3 adrenergic agonists.

Technology Process of 5-CHLOROMETHYL-2-TRITYL-2H-TETRAZOLE

There total 1 articles about 5-CHLOROMETHYL-2-TRITYL-2H-TETRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloromethyl-1H-tetrazole (55408-11-2) + trityl chloride (76-83-5) → (2-triphenylmethyltetrazol-5-yl)methyl chloride (160998-59-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane;

Reference yield: 100.0%

(2-triphenylmethyltetrazol-5-yl)methyl chloride (160998-59-4) + C19H18N6O2 (1431873-01-6) → C40H34N10O2 (1431873-09-4)

Guidance literature:

C₁₉H₁₈N₆O₂; With sodium hydride; In N,N-dimethyl-formamide; at 10 ℃; for 0.5h; Inert atmosphere;

(2-triphenylmethyltetrazol-5-yl)methyl chloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 100.0%

(2-triphenylmethyltetrazol-5-yl)methyl chloride (160998-59-4) + 4-(2,6-dimethoxyphenyl)-5-(5-methylfuran-2-yl)-4H-1,2,4-triazole-3-thiol → 5-({[4-(2,6-dimethoxyphenyl)-5-(5-methylfuran-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}methyl)-2-trityl-2H-tetrazole

Guidance literature:

(2-triphenylmethyltetrazol-5-yl)methyl chloride; 4-(2,6-dimethoxyphenyl)-5-(5-methylfuran-2-yl)-4H-1,2,4-triazole-3-thiol; With potassium carbonate; In acetone; at 60 ℃; for 1h;

With pentan-3-one; In acetone; at 100 ℃; for 1h;

upstream raw materials:

5-chloromethyl-1H-tetrazole

trityl chloride

Downstream raw materials:

C₄₀H₃₄N₁₀O₂

Refernces

• 1、 -. "SELECTIVE BETA3 ADRENERGIC AGONISTS". . . Retrieved 2015/09/24.