4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole

Base Information

Chemical Name:4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole
CAS No.:915412-20-3
Molecular Formula:C₃₁H₃₈BrNO₂Si
Molecular Weight:564.638
Hs Code.:

Synonyms:4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole

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Chemical Property of 4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole

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Technology Process of 4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole

There total 9 articles about 4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 915412-19-0
1-bromo-3-iodo-5-(4-methoxybenzyloxy)benzene

: 690632-17-8
4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-1-(triisopropylsilyl)-1H-indole

: 915412-20-3
4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 90 ℃; for 14h;

Reference yield:

: 570391-20-7
3-bromo-5-iodophenol

: 915412-20-3
4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 14 h / 90 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene; 2: Suzuki coupling;
DOI:10.1021/jm100659v

Reference yield:

: 52488-36-5
4-bromo-1H-indole

: 915412-20-3
4-(3-bromo-5-(4-methoxybenzyloxy)phenyl)-1-(triisopropylsilyl)-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 4 h / 90 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 5 °C

2.2: 0 - 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 14 h / 90 °C

With potassium acetate; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; toluene; 3.1: Suzuki Coupling;