4-phenyl-1-((4-(trifluoromethyl)phenyl)-sulfonyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: 4-phenyl-1-((4-(trifluoromethyl)phenyl)-sulfonyl)-1H-1,2,3-triazole
• CAS No.: 1312680-91-3
• Molecular Formula: C₁₅H₁₀F₃N₃O₂S
• Molecular Weight: 353.325
• Mol file: 1312680-91-3.mol

Synonyms:4-phenyl-1-((4-(trifluoromethyl)phenyl)-sulfonyl)-1H-1,2,3-triazole

Chemical Property of 4-phenyl-1-((4-(trifluoromethyl)phenyl)-sulfonyl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-phenyl-1-((4-(trifluoromethyl)phenyl)-sulfonyl)-1H-1,2,3-triazole

There total 2 articles about 4-phenyl-1-((4-(trifluoromethyl)phenyl)-sulfonyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(trifluoromethyl)benzenesulfonyl azide (1152979-96-8) + phenylacetylene (536-74-3) → 4-phenyl-1-((4-(trifluoromethyl)phenyl)-sulfonyl)-1H-1,2,3-triazole (1312680-91-3)

Guidance literature:

With copper(I) thiophene-2-carboxylate; benzoic acid; In benzene; at 60 ℃; for 0.0166667h; Flow reactor;

Reference yield:

4-trifluorophenylsulfonyl chloride (2991-42-6) → 4-phenyl-1-((4-(trifluoromethyl)phenyl)-sulfonyl)-1H-1,2,3-triazole (1312680-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / water; acetone / 3 h / 0 - 20 °C

2: copper(I) thiophene-2-carboxylate / toluene / 20 °C

With sodium azide; copper(I) thiophene-2-carboxylate; In water; acetone; toluene;

DOI:10.1021/ja202969z

Reference yield: 98.0%

bromocyane (506-68-3) + 4-phenyl-1-((4-(trifluoromethyl)phenyl)-sulfonyl)-1H-1,2,3-triazole (1312680-91-3) → 2-bromo-4-phenyl-1-((4-(trifluoromethyl)phenyl)sulfonyl)-1H-imidazole

Guidance literature:

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; In benzene; at 70 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00977

upstream raw materials:

4-(trifluoromethyl)benzenesulfonyl azide

phenylacetylene

4-trifluorophenylsulfonyl chloride

Downstream raw materials:

(S)-(-)-N-(2-cyclohexyl-2-phenylethyl)-4-(trifluoromethyl)benzenesulfonamide

N-(2,2-diphenylvinyl)-4-(trifluoromethyl)benzenesulfonamide

(Z)-N-(1-(dimethylamino)-3-oxo-1,3-diphenylprop-1-en-2-yl)-4-(trifluoromethyl)benzenesulfonamide

C₂₄H₂₁F₃N₂O₃S