1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate

Base Information

Chemical Name:1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate
CAS No.:885020-49-5
Molecular Formula:C₃₆H₅₁F₂NO₉SSi
Molecular Weight:739.951
Hs Code.:

1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate

Synonyms:1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate

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Chemical Property of 1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate

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Technology Process of 1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate

There total 1 articles about 1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885020-48-4
(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-ol

: 34582-32-6
N-tert-butoxycarbonyl aspartic acid tert-butyl ester

: 885020-49-5
1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate

Guidance literature:: N-tert-butoxycarbonyl aspartic acid tert-butyl ester; With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; for 0.0833333h;

(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-ol; In N,N-dimethyl-formamide; for 16h;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; more than 3 stages;

Reference yield:

: 885020-49-5
1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate

: C₃₀H₃₇F₂NO₉S

Guidance literature:: 1-tert-butyl 4-{(2Z)-4-{[tert-butyl(dimethyl)silyl]oxy}-3-(3,4-difluorophenyl)-2-[4-(methylsulfonyl)phenyl]but-2-en-1-yl} N-(tert-butoxycarbonyl)aspartate; With fluorosilicic acid; water; In acetonitrile; tert-butyl alcohol; for 2h;

In water; acetonitrile; tert-butyl alcohol; pH=7;