2,2-dimethyl-N-(2-(2-chloro-5,6-dimethyl-3-fluoro-4-pyridyl)phenyl)propanamide

Base Information

• Chemical Name: 2,2-dimethyl-N-(2-(2-chloro-5,6-dimethyl-3-fluoro-4-pyridyl)phenyl)propanamide
• CAS No.: 179676-88-1
• Molecular Formula: C₁₈H₂₀ClFN₂O
• Molecular Weight: 334.821
• Mol file: 179676-88-1.mol

Synonyms:2,2-dimethyl-N-(2-(2-chloro-5,6-dimethyl-3-fluoro-4-pyridyl)phenyl)propanamide

Chemical Property of 2,2-dimethyl-N-(2-(2-chloro-5,6-dimethyl-3-fluoro-4-pyridyl)phenyl)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dimethyl-N-(2-(2-chloro-5,6-dimethyl-3-fluoro-4-pyridyl)phenyl)propanamide

There total 1 articles about 2,2-dimethyl-N-(2-(2-chloro-5,6-dimethyl-3-fluoro-4-pyridyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-pivaloylaminophenyl boronic acid (146140-95-6) + 2-chloro-5,6-dimethyl-3-fluoro-4-iodopyridine (150127-29-0) → 2,2-dimethyl-N-(2-(2-chloro-5,6-dimethyl-3-fluoro-4-pyridyl)phenyl)propanamide (179676-88-1)

Guidance literature:

With barium dihydroxide; ethanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 80 ℃; for 16h; Product distribution; cross-coupling reaction between sterically hindered 3-fluoro- and 3-aminopyridines with arylboronic acids; reagent also aq.Na₂CO₃; steric and electronic effects;

DOI:10.1016/0022-328X(95)05979-Y

Reference yield: 67.0%

(2-quinolyl)trimethylstannane (79476-04-3) + 2,2-dimethyl-N-(2-(2-chloro-5,6-dimethyl-3-fluoro-4-pyridyl)phenyl)propanamide (179676-88-1) → N-[2-(3-Fluoro-5,6-dimethyl-2-quinolin-2-yl-pyridin-4-yl)-phenyl]-2,2-dimethyl-propionamide

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 60h; Heating;

DOI:10.1016/S0040-4039(00)60486-0

upstream raw materials:

2-pivaloylaminophenyl boronic acid

2-chloro-5,6-dimethyl-3-fluoro-4-iodopyridine