tert-butyl {(tert-butoxy)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-carbonylamino}formate

Base Information

Chemical Name:tert-butyl {(tert-butoxy)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-carbonylamino}formate
CAS No.:1217303-70-2
Molecular Formula:C₁₇H₂₁F₄NO₄
Molecular Weight:379.352
Hs Code.:

Synonyms:tert-butyl {(tert-butoxy)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-carbonylamino}formate

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Chemical Property of tert-butyl {(tert-butoxy)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-carbonylamino}formate

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Technology Process of tert-butyl {(tert-butoxy)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-carbonylamino}formate

There total 1 articles about tert-butyl {(tert-butoxy)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-carbonylamino}formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 123973-25-1
2-fluoro-3-(trifluoromethyl)aniline

: 1217303-70-2
tert-butyl {(tert-butoxy)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-carbonylamino}formate

Guidance literature:: With dmap; In tetrahydrofuran; Reflux;

Reference yield: 52.0%

: 1217303-70-2
tert-butyl {(tert-butoxy)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-carbonylamino}formate

: 1217303-71-3
tert-butyl 2-fluoro-3-(trifluoromethyl)phenylcarbamate

Guidance literature:: With potassium carbonate; In methanol; for 2h; Reflux;

Reference yield:

: 1217303-70-2
tert-butyl {(tert-butoxy)-N-[2-fluoro-3-(trifluoromethyl)phenyl]-carbonylamino}formate

: 1217303-26-8
6-bromo-2-fluoro-3-(trifluoromethyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / 2 h / Reflux

2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -70 - 50 °C

2.2: 1 h / -70 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With tert.-butyl lithium; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;