tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate

Base Information

Chemical Name:tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate
CAS No.:1310114-14-7
Molecular Formula:C₄₁H₆₃N₃O₁₁Si
Molecular Weight:802.05
Hs Code.:

tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate

Synonyms:tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate

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Chemical Property of tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate

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Technology Process of tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate

There total 2 articles about tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1310113-99-5
tert-butyl (2R,3R)-2-(2-(diethoxy(methyl)silyl)allyloxy)-4-(2-(hex-5-enyloxy)-N-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-5-nitrobenzamido)-3-methylbutyl(methyl)carbamate

: 1310114-14-7
tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate

Guidance literature:: With C₄₄H₆₁Cl₂N₂PRu; In toluene; at 36 ℃; for 12h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ja202012s

Reference yield:

: 2031-62-1
diethoxymethylane

: 1310114-55-6
C₃₈H₅₃N₃O₉

: 1310114-14-7
tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

2: C₄₄H₆₁Cl₂N₂PRu / toluene / 12 h / 36 °C / Inert atmosphere

With cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; C₄₄H₆₁Cl₂N₂PRu; In dichloromethane; toluene;
DOI:10.1021/ja202012s

Reference yield: 86.0%

: 1310114-14-7
tert-butyl ((10R,11R,E)-7-(diethoxy(methyl)silyl)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate

: 1310114-26-1
tert-butyl ((10R,11R,Z)-13-((S)-1-(4-methoxybenzyloxy)propan-2-yl)-11-methyl-16-nitro-14-oxo-2,3,4,5,8,10,11,12,13,14-decahydrobenzo[b][1,9,5]dioxaazacyclohexadecin-10-yl)methyl(methyl)carbamate

Guidance literature:: With tetrabutyl ammonium fluoride; silver fluoride; acetic acid; In tetrahydrofuran; for 2h; Inert atmosphere; Darkness;
DOI:10.1021/ja202012s