3-[3-(Trifluoromethyl)phenyl]pyrrolidine

Base Information

Chemical Name:3-[3-(Trifluoromethyl)phenyl]pyrrolidine
CAS No.:21767-35-1
Molecular Formula:C₁₁H₁₂F₃N
Molecular Weight:215.218
Hs Code.:
European Community (EC) Number:829-092-8
ChEMBL ID:CHEMBL3706603
Mol file:21767-35-1.mol

Synonyms:3-[3-(trifluoromethyl)phenyl]pyrrolidine;21767-35-1;3-(3-(Trifluoromethyl)phenyl)pyrrolidine;3-(3-TRIFLUOROMETHYL-PHENYL)-PYRROLIDINE;CHEMBL3706603;Pyrrolidine,3-[3-(trifluoromethyl)phenyl]-, hydrochloride (1:1);3-(3-TRIFLUOROMETHYLPHENYL)PYRROLIDINE;Pyrrolidine, 3-[3-(trifluoromethyl)phenyl]-;SCHEMBL6352759;DUYDZGBSZJZIOZ-UHFFFAOYSA-N;WAA76735;BDBM50214806;MFCD09608132;AKOS011344158;SB35471;3-(3-(trifluoromethyl)phenyl)-pyrrolidine;BB 0260347;CS-0112203;FT-0752866;EN300-134250;Y13904;F2148-1385;8-chloro-3a,4-dihydro-6-(2-fluorophenyl)-1-methyl-3h-imidazo[1,5-a][1,4]benzodiazepine

Suppliers and Price of 3-[3-(Trifluoromethyl)phenyl]pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-[3-(trifluoromethyl)phenyl]pyrrolidine
25mg
$ 110.00

SynQuest Laboratories
3-[3-(Trifluoromethyl)phenyl]pyrrolidine 97%
1 g
$ 795.00

Matrix Scientific
3-[3-(Trifluoromethyl)phenyl]pyrrolidine
500mg
$ 350.00

Matrix Scientific
3-[3-(Trifluoromethyl)phenyl]pyrrolidine
1mg
$ 600.00

Matrix Scientific
3-[3-(Trifluoromethyl)phenyl]pyrrolidine
2.500g
$ 1200.00

J&W Pharmlab
3-(3-Trifluoromethyl-phenyl)-pyrrolidine 98%
5g
$ 1320.00

J&W Pharmlab
3-(3-Trifluoromethyl-phenyl)-pyrrolidine 98%
500mg
$ 215.00

J&W Pharmlab
3-(3-Trifluoromethyl-phenyl)-pyrrolidine 98%
250mg
$ 158.00

J&W Pharmlab
3-(3-Trifluoromethyl-phenyl)-pyrrolidine 98%
100mg
$ 129.00

J&W Pharmlab
3-(3-Trifluoromethyl-phenyl)-pyrrolidine 98%
50mg
$ 109.00

Total 8 raw suppliers

Chemical Property of 3-[3-(Trifluoromethyl)phenyl]pyrrolidine

Chemical Property:

Boiling Point:239.9±40.0 °C(Predicted)
PKA:10.00±0.10(Predicted)
Density:1.179±0.06 g/cm3(Predicted)
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:215.09218387
Heavy Atom Count:15
Complexity:214

Purity/Quality:

97% ^*data from raw suppliers

3-[3-(trifluoromethyl)phenyl]pyrrolidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCC1C2=CC(=CC=C2)C(F)(F)F

Technology Process of 3-[3-(Trifluoromethyl)phenyl]pyrrolidine

There total 6 articles about 3-[3-(Trifluoromethyl)phenyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 861965-61-9
1-benzyl-3-[3-(trifluoromethyl)phenyl]pyrrolidine

: 21767-35-1
3-(3-(trifluoromethyl)phenyl)pyrrolidine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; at 60 ℃; for 12h;

Reference yield:

: 60050-38-6
3-(3-trifluoromethyl-phenyl)-pyrrolidine-2,5-dione

: 21767-35-1
3-(3-(trifluoromethyl)phenyl)pyrrolidine

Guidance literature:: With borane-THF; In tetrahydrofuran; at 0 ℃; for 3.5h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2013.11.011

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 21767-35-1
3-(3-(trifluoromethyl)phenyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: i-Pr₂NEt, Ag₂CO₃, P(o-Tol)3 / Pd(OAc)2 / dimethylformamide / 100 °C

2: HCO₂NH₄ / Pd/C / methanol / 4 h / Heating

3: aq. HCl / methanol / Heating

With hydrogenchloride; ammonium formate; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; silver carbonate; palladium diacetate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(96)00618-X