2-METHOXY-4-(TRIFLUOROMETHYL)-PHENYLBORONIC ACID

Base Information

• Chemical Name: 2-METHOXY-4-(TRIFLUOROMETHYL)-PHENYLBORONIC ACID
• CAS No.: 312936-89-3
• Molecular Formula: C8H8BF3O3
• Molecular Weight: 219.956
• Hs Code.: 2931900090
• Mol file: 312936-89-3.mol

Synonyms:Boronicacid, [2-methoxy-4-(trifluoromethyl)phenyl]- (9CI);

Chemical Property of 2-METHOXY-4-(TRIFLUOROMETHYL)-PHENYLBORONIC ACID

Chemical Property:

• Vapor Pressure: 0.000267mmHg at 25°C
• Refractive Index: 1.464
• Boiling Point: 309.9 °C at 760 mmHg
• PKA: 7.84±0.58(Predicted)
• Flash Point: 141.2 °C
• PSA: 49.69000
• Density: 1.36 g/cm³
• LogP: 0.39380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Methoxy-4-trifluoromethylphenylboronic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHOXY-4-(TRIFLUOROMETHYL)-PHENYLBORONIC ACID

There total 3 articles about 2-METHOXY-4-(TRIFLUOROMETHYL)-PHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Triisopropyl borate (5419-55-6) + 3-(trifluoromethyl)anisole (454-90-0) → (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid (312936-89-3)

Guidance literature:

3-(trifluoromethyl)anisole; With n-butyllithium; In tetrahydrofuran; hexanes; at 0 ℃; for 2h;

Triisopropyl borate; In tetrahydrofuran; hexanes; at 0 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; hexanes; water; for 1h;

Reference yield:

C14H20BF3O3 → (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid (312936-89-3)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; hexanes; water; for 1h;

Reference yield:

3-(trifluoromethyl)anisole (454-90-0) → (2-methoxy-4-(trifluoromethyl)phenyl)boronic acid (312936-89-3)

Guidance literature:

3-(trifluoromethyl)anisole; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

With Triisopropyl borate; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; for 1h;

DOI:10.1021/jm101414h

upstream raw materials:

Triisopropyl borate

3-(trifluoromethyl)anisole

Downstream raw materials:

4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-methylpyridine hydrochloride

4-(2-methoxy-4-(trifluoromethyl)phenyl)piperidine

Refernces

• 1、 -. "AZABENZIMIDAZOLYL COMPOUNDS". Page/Page column 66. . Retrieved 2008/06/13.