[3-(3-bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine

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Chemical Name:[3-(3-bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine
CAS No.:1386399-17-2
Molecular Formula:C₂₃H₃₃BrN₆O₂Si
Molecular Weight:533.544
Hs Code.:

Synonyms:[3-(3-bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine

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Chemical Property of [3-(3-bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine

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Technology Process of [3-(3-bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine

There total 4 articles about [3-(3-bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.7%

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1386399-15-0
3-(3-bromo-phenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1386399-17-2
[3-(3-bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: 3-(3-bromo-phenyl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine; (2-trimethylethylsilylethoxy)methyl chloride; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-(2-AMINOETHYL)MORPHOLINE; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1386399-14-9
(3-bromo-phenyl)-(2,4-dichloro-pyrimidin-5-yl)-methanone

: 1386399-17-2
[3-(3-bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine / tetrahydrofuran / 0.67 h / 20 - 50 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 1 h / 20 °C

With triethylamine; hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1386399-13-8
(3-bromo-phenyl)-(2,4-dichloro-pyrimidin-5-yl)-methanol

: 1386399-17-2
[3-(3-bromo-phenyl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]-(2-morpholin-4-yl-ethyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 2 h / 0 °C

2.1: hydrazine / tetrahydrofuran / 0.67 h / 20 - 50 °C

3.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 1 h / 20 °C

With sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; triethylamine; hydrazine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;