(R)-1-ethoxy-1-oxopropan-2-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Base Information

Chemical Name:(R)-1-ethoxy-1-oxopropan-2-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
CAS No.:39532-65-5
Molecular Formula:C₁₅H₁₇F₃O₅
Molecular Weight:334.292
Hs Code.:

Synonyms:(R)-1-ethoxy-1-oxopropan-2-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-ethoxy-1-oxopropan-2-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

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Technology Process of (R)-1-ethoxy-1-oxopropan-2-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

There total 3 articles about (R)-1-ethoxy-1-oxopropan-2-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 17257-71-5,20445-31-2,56135-03-6,81655-41-6
(S)-Mosher acid

: ethyl (S)-2-{[(prop-2-yn-1-ylthio)carbonothioyl]oxy}propanoate

: 39532-65-5
(R)-1-ethoxy-1-oxopropan-2-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: In toluene; enantioselective reaction; Inert atmosphere; Reflux;
DOI:10.1055/s-0035-1562449

Reference yield:

: 687-47-8
(S)-Ethyl lactate

: 39532-65-5
(R)-1-ethoxy-1-oxopropan-2-yl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

1.2: 0 - 20 °C

2.1: toluene / Inert atmosphere; Reflux

With sodium hydride; In tetrahydrofuran; toluene;
DOI:10.1055/s-0035-1562449