1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate

Base Information

Chemical Name:1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate
CAS No.:252919-24-7
Molecular Formula:C₃₃H₃₇NO₇
Molecular Weight:559.659
Hs Code.:

Synonyms:1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate

Suppliers and Price of 1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate

There total 10 articles about 1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 252919-23-6
4-benzyl 1-tert-butyl (2S,3R)-2-allyl-3-({benzyl[(benzyloxy)carbonyl]amino}methyl)butanedioate

: 252919-24-7
1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate

Guidance literature:: With ozone; triphenylphosphine; In dichloromethane; at 20 ℃;
DOI:10.1021/jo016086b

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 252919-24-7
1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran / 1 h / -78 °C

1.2: 75 percent / tetrahydrofuran / 5 h / -30 °C

2.1: 90 percent / 30percent H₂O₂; aq. LiOH / tetrahydrofuran; H₂O / 2 h / 0 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: 80 percent / tetrahydrofuran / 5 h / -30 °C

4.1: 87 percent / DBU / benzene / 2 h / 60 °C

5.1: 78 percent / O₃; triphenylphosphine / CH₂Cl₂ / 20 °C

With lithium hydroxide; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; benzene;
DOI:10.1021/jo016086b

Reference yield:

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 252919-24-7
1-benzyl 4-tert-butyl (2R,3S)-2-({benzyl[(benzyloxy)carbonyl]amino}methyl)-3-(2-oxoethyl)butanedioate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 90 percent / NaH / tetrahydrofuran; dimethylformamide / 20 °C

2.1: Et₃N / tetrahydrofuran / 1 h / -30 °C

3.1: 55.4 g / LiCl / tetrahydrofuran / 20 °C

4.1: LDA / tetrahydrofuran / 1 h / -78 °C

4.2: 75 percent / tetrahydrofuran / 5 h / -30 °C

5.1: 90 percent / 30percent H₂O₂; aq. LiOH / tetrahydrofuran; H₂O / 2 h / 0 °C

6.1: LDA / tetrahydrofuran / 1 h / -78 °C

6.2: 80 percent / tetrahydrofuran / 5 h / -30 °C

7.1: 87 percent / DBU / benzene / 2 h / 60 °C

8.1: 78 percent / O₃; triphenylphosphine / CH₂Cl₂ / 20 °C

With lithium hydroxide; sodium hydride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo016086b