methyl 7α-benzoyloxy-3α-(N-Boc-N,O-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate

Base Information

Chemical Name:methyl 7α-benzoyloxy-3α-(N-Boc-N,O-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate
CAS No.:870133-62-3
Molecular Formula:C₄₈H₆₂F₃NO₁₁
Molecular Weight:886.016
Hs Code.:

Synonyms:methyl 7α-benzoyloxy-3α-(N-Boc-N,O-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate

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Chemical Property of methyl 7α-benzoyloxy-3α-(N-Boc-N,O-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate

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Technology Process of methyl 7α-benzoyloxy-3α-(N-Boc-N,O-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate

There total 4 articles about methyl 7α-benzoyloxy-3α-(N-Boc-N,O-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 870133-59-8
methyl 7α-benzoyloxy-3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-12α-trifluoroacetoxy-5β-cholan-24-oate

: 870133-62-3
methyl 7α-benzoyloxy-3α-(N-Boc-N,O-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 3h;
DOI:10.1002/ejoc.200500203

Reference yield:

: 870133-56-5
methyl 3α-[N-Boc-N,O-(4-methoxybenzylidene)-β-phenylisoserinoyl]-7α-hydroxy-12α-trifluoroacetoxy-5β-cholan-24-oate

: 870133-62-3
methyl 7α-benzoyloxy-3α-(N-Boc-N,O-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 4-(dimethylamino)pyridine / pyridine / 3 h / 90 °C

2: 68 percent / PTSA / methanol / 3 h / 20 °C

With dmap; toluene-4-sulfonic acid; In pyridine; methanol;
DOI:10.1002/ejoc.200500203

Reference yield:

: 130782-01-3
Methyl 3α,7α-dihydroxy-12α-trifluoroacetyloxy-5β-cholan-24-oate

: 870133-62-3
methyl 7α-benzoyloxy-3α-(N-Boc-N,O-β-phenylisoserinoyl)-12α-trifluoroacetoxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / toluene / 16 h / 80 °C

2: 82 percent / 4-(dimethylamino)pyridine / pyridine / 3 h / 90 °C

3: 68 percent / PTSA / methanol / 3 h / 20 °C

With dmap; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In pyridine; methanol; toluene;
DOI:10.1002/ejoc.200500203