(2R,3S)-1-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-3-(2-naphthyl)aziridine-2-carboxamide

Base Information

Chemical Name:(2R,3S)-1-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-3-(2-naphthyl)aziridine-2-carboxamide
CAS No.:1073903-24-8
Molecular Formula:C₂₅H₂₆N₂O₄
Molecular Weight:418.492
Hs Code.:

Synonyms:(2R,3S)-1-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-3-(2-naphthyl)aziridine-2-carboxamide

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Chemical Property of (2R,3S)-1-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-3-(2-naphthyl)aziridine-2-carboxamide

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Technology Process of (2R,3S)-1-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-3-(2-naphthyl)aziridine-2-carboxamide

There total 2 articles about (2R,3S)-1-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-3-(2-naphthyl)aziridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 479423-45-5
tert-butyl naphthalen-2-ylmethylenecarbamate

: 147666-25-9
2-diazo-N-(4-methoxyphenyl)acetamide

: 1073903-24-8
(2R,3S)-1-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-3-(2-naphthyl)aziridine-2-carboxamide

: (Z)-3-(t-butoxycarbonylamino)-N-(4-methoxyphenyl)-2-(2-naphthyl)acrylamide

Guidance literature:: With (R)-3,3'-dimesityl-1,1'-binaphthyl-2,2'-dicarboxylic acid; In toluene; at 0 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Molecular sieve;
DOI:10.1021/ja805635c

Reference yield:

: 479423-45-5
tert-butyl naphthalen-2-ylmethylenecarbamate

: 147666-25-9
2-diazo-N-(4-methoxyphenyl)acetamide

: 1073903-24-8
(2R,3S)-1-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-3-(2-naphthyl)aziridine-2-carboxamide

: 1172132-99-8
(2S,3R)-1-(t-butoxycarbonyl)-N-(4-methoxyphenyl)-3-(2-naphthyl)aziridine-2-carboxamide

Guidance literature:: With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In dichloromethane; at 20 ℃; for 0.166667h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol901047w